Prenatal stress: Effects on fetal and child brain development

A Lautarescu, MC Craig, V Glover - International review of neurobiology, 2020 - Elsevier
The impact of stress on brain health begins in the womb. Both animal and human studies
have found that prenatal maternal stress affects the brain and behavior of the offspring …

Prenatal stress effects on offspring brain and behavior: Mediators, alterations and dysregulated epigenetic mechanisms

SU Haq, UA Bhat, A Kumar - Journal of biosciences, 2021 - Springer
Prenatal environment significantly influences mammalian fetal development and adverse in
utero conditions have life-long consequences for the offspring health. Research has …

[HTML][HTML] Role of brain modulators in neurodevelopment: focus on autism spectrum disorder and associated comorbidities

AK Saad, A Akour, A Mahboob, S AbuRuz, B Sadek - Pharmaceuticals, 2022 - mdpi.com
Autism spectrum disorder (ASD) and associated neurodevelopmental disorders share
similar pathogenesis and clinical features. Pathophysiological changes in these diseases …

Behavioural outcomes of perinatal maternal fluoxetine treatment

BB McAllister, V Kiryanova, RH Dyck - Neuroscience, 2012 - Elsevier
During and following pregnancy, women are at considerable risk of experiencing
depression. For treatment, selective serotonin reuptake inhibitor drugs, such as fluoxetine …

Mood changes after delivery: role of the serotonin transporter gene

J Sanjuan, R Martin-Santos… - The British Journal of …, 2008 - cambridge.org
BackgroundPolymorphic variations in the serotonin transporter gene (5-HTT) moderate the
depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction in …

Serotonin, pregnancy and increased autism prevalence: is there a link?

N Hadjikhani - Medical hypotheses, 2010 - Elsevier
The prevalence of autism, a neurodevelopmental condition resulting from genetic and
environmental causes, has increased dramatically during the last decade. Among the …

Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice

MS Ansorge, E Morelli, JA Gingrich - Journal of Neuroscience, 2008 - Soc Neuroscience
Serotonin (5-HT) acts as a neurotransmitter, but also modulates brain maturation during
early development. The demonstrated influence of genetic variants on brain function …

Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress

PM Hecht, M Hudson, SL Connors, MR Tilley… - Autism …, 2016 - Wiley Online Library
Stress exposure during gestation is implicated in several neuropsychiatric conditions,
including autism spectrum disorder (ASD). Previous research showed that prenatal stress …

[HTML][HTML] The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring

JDA Olivier, H Åkerud, H Kaihola… - Frontiers in cellular …, 2013 - frontiersin.org
It has been estimated that 20% of pregnant women suffer from depression and it is well-
documented that maternal depression can have long-lasting effects on the child. Currently …

Developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the PFC and hippocampus of offspring at weaning

M Gemmel, I Rayen, T Lotus… - Developmental …, 2016 - Wiley Online Library
Selective serotonin reuptake inhibitor medication exposure during the perinatal period can
have a long term impact in adult offspring on neuroplasticity and the serotonergic system …