Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood

R Hiroi, DL Carbone, DG Zuloaga, HA Bimonte-Nelson… - Neuroscience, 2016 - Elsevier
Prenatal stress and overexposure to glucocorticoids (GC) during development may be
associated with an increased susceptibility to a number of diseases in adulthood including …

The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress

BD Sachs, RM Rodriguiz, WB Siesser… - International Journal …, 2013 - academic.oup.com
Abstract Aberrant serotonin (5-HT) signalling and exposure to early life stress have both
been suggested to play a role in anxiety-and impulsivity-related behaviours. However …

Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy

BRH Van den Bergh, MI van den Heuvel… - Neuroscience & …, 2020 - Elsevier
Accumulating research shows that prenatal exposure to maternal stress increases the risk
for behavioral and mental health problems later in life. This review systematically analyzes …

[HTML][HTML] Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene× environment interactions

D Van den Hove, SB Jakob, KG Schraut, G Kenis… - PloS one, 2011 - journals.plos.org
Prenatal stress (PS) has been shown to influence the development of the fetal brain and to
increase the risk for the development of psychiatric disorders in later life. Furthermore, the …

[HTML][HTML] Amygdala 5-HTT gene network moderates the effects of postnatal adversity on attention problems: anatomo-functional correlation and epigenetic changes

RMS De Lima, B Barth, DM Arcego… - Frontiers in …, 2020 - frontiersin.org
Variations in serotoninergic signaling have been related to behavioral outcomes. Alterations
in the genome, such as DNA methylation and histone modifications, are affected by …

[HTML][HTML] Maternal perinatal depression and child neurocognitive development: A relationship still to be clarified

M Severo, A Ventriglio, A Bellomo, S Iuso… - Frontiers in …, 2023 - frontiersin.org
Pregnancy frequently is associated with emotional conditions such as anxiety and
depression. Perinatal depression has an incidence of around 12%. Only recently researcher …

Pathway of maternal serotonin to the human embryo and fetus

HJ Kliman, SB Quaratella, AC Setaro… - …, 2018 - academic.oup.com
Abstract Serotonin [5-hydroxytryptamine (5-HT)] is essential to intrauterine development, but
its source is debated. We used immunocytochemistry to gauge 5-HT, its biosynthetic enzyme …

Gestational hormone profiles predict human maternal behavior at 1-year postpartum

LM Glynn, EP Davis, CA Sandman… - Hormones and behavior, 2016 - Elsevier
In many non-human species, including primates, gestational reproductive hormones play an
essential role in the onset of maternal motivation and behaviors. We investigated the …

[HTML][HTML] Placental CRH as a signal of pregnancy adversity and impact on fetal neurodevelopment

I Kassotaki, G Valsamakis, G Mastorakos… - Frontiers in …, 2021 - frontiersin.org
Early life is a period of considerable plasticity and vulnerability and insults during that period
can disrupt the homeostatic equilibrium of the developing organism, resulting in adverse …

Prenatal stress induces schizophrenia-like alterations of serotonin 2A and metabotropic glutamate 2 receptors in the adult offspring: role of maternal immune system

T Holloway, JL Moreno, A Umali… - Journal of …, 2013 - Soc Neuroscience
It has been suggested that severe adverse life events during pregnancy increase the risk of
schizophrenia in the offspring. The serotonin 5-HT2A and the metabotropic glutamate 2 …