Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to
resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous …

In osteoclasts (OCs) podosomes are organized in a belt, a feature critical for bone
resorption. Although microtubules (MTs) promote the formation and stability of the belt, the …

Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but
how sclerostin production is regulated in osteocytes remains unclear. Here, we show that …

Increased bone resorption by osteoclasts after estrogen deficiency is the main cause of
postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) is a DNA …

ABSTRACT A reduction in trabecular bone mass is often associated with an increase in
marrow fat in osteoporotic bones. The molecular mechanisms underlying this inverse …

Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature
osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the …

Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology
throughout their differentiation. Altered osteoclast differentiation and activity lead to changes …

Autophagy is an important mechanosensitive response for cellular homeostasis and survival
in osteocytes. However, the mechanism and its effect on bone metabolism have not yet …

The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the
pathogenesis of various diseases, including cancer, obesity, and cardiovascular disease …

The receptor activator of nuclear factor-κB (RANK) protein activates various protein kinase
signaling cascades, including those involving NF-κB, mitogen-activated protein kinase …