There is overwhelming evidence that solid human tumours grow within a unique micro-
environment. This environment is characterised by an abnormal vasculature, which leads to …

Solid tumours contain regions at very low oxygen concentrations (hypoxia), often
surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both …

Tumour hypoxia is a major constraint for radiotherapy and many types of chemotherapy. A
variety of different pathogenetic mechanisms contribute to the development of hypoxia in …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …

Tissue hypoxia occurs where there is an imbalance between oxygen supply and
consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of …

Poor microenvironmental conditions are a characteristic feature of solid tumors. Such
conditions occur because the tumor vascular supply, which develops from the normal host …

Tumour hypoxia has been found to be a characteristic feature in many solid tumours. It has
been shown to decrease the therapeutic efficacy of radiation treatment, surgery and some …

Tumour hypoxia is the result of an imbalance in oxygen supply and demand. It is an adverse
prognostic indicator in cancer as it modulates tumour progression and treatment. Many …

Tumor hypoxia has long been recognized as a critical issue in oncology. Resistance of
hypoxic areas has been shown to affect treatment outcome after radiation, chemotherapy …

A major feature of solid tumours is hypoxia, decreased availability of oxygen, which
increases patient treatment resistance and favours tumour progression. How hypoxic …