The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides
important signals regulating clonal expansion, antibody production and isotype switching, as …

This article brings together information garnered over the last 10 years on the B cell-
associated CD40 surface glycoprotein. The discovery in 1992 of a natural counterstructure …

The CD40‐CD40 ligand (CD40L) interaction is one of the most important receptor− ligand
interactions that occurs during a T dependent immune response. However, while CD40L is …

Abstract CD40 and CD40 ligand (CD40L) form one of most important receptor‐ligand pairs
that dock during T‐B cell interactions as part of T‐dependent antibody responses. It has …

Publisher Summary This chapter focuses on the role of CD40 and its ligand, gp39, as central
players in the regulation of B cell growth and differentiation. Reciprocal activation requires …

CD40 is a 48 kDa glycoprotein predominantly expressed on B cells in both mouse and man,
which interacts with a counterligand (CD40L), expressed on activated CD4+ T cells …

▪ Abstract Over the past three years, CD40 and its ligand (gp39, CD40L, TBAM) have been
shown to be essential for humoral immune responses to thymus-dependent antigens …

Naive and memory B-lymphocyte populations can be activated through the binding of
CD154 to CD40, a receptor that is constitutively expressed on the surface of these cells …

B cells can be stimulated to proliferate and differentiate in response to cell-contact
dependent signals provided by activated, but not resting, T cells. In the human system …

During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …