Introduction: Gender is increasingly recognized as a key factor in trauma and sepsis.
Multiple clinical and experimental studies on sepsis have shown a distinct advantage of …

An analysis of current literature on sexual dimorphism in response to trauma-hemorrhage
revealed conflicting reports on the role of gender in outcomes of trauma patients. In contrast …

Several clinical studies show a gender dimorphism of immune and organ responsiveness in
the susceptibility to and morbidity from shock, trauma, and sepsis. However, there are …

During sepsis, a complex network of cytokine, immune, and endothelial cell interactions
occur and disturbances in the microcirculation cause organ dysfunction or even failure …

Although several clinical studies show a gender dimorphism of immune and organ
responsiveness in the susceptibility to and morbidity from shock, trauma, and sepsis, there …

Publisher Summary Systemic inflammatory response syndrome (SIRS) is a clinical
syndrome characterized by systemic inflammation and widespread tissue injury. SIRS is …

Despite efforts in prevention and intensive care, trauma and subsequent sepsis are still
associated with a high mortality rate. Traumatic injury remains the main cause of death in …

Several lines of evidence indicate that female sex is a protective factor in trauma and
hemorrhage. In both clinical and experimental studies, proestrus females have been shown …

Several clinical and experimental studies have demonstrated gender dimorphism in immune
and organ responsiveness and in the susceptibility to and morbidity from shock, trauma, and …

In this mini-review we provide an overview of sex-and gender-dependent issues in both
clinical and preclinical sepsis. The increasing recognition for the need to account for sex and …