Mitochondrial dysfunction plays an important role in the pathogenesis and progression of
diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction …

Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease
(DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

Diabetic kidney disease (DKD) is a common microvascular complication among diabetic
patients. Once the DKD has developed, most of the patients inevitably progress to the end …

The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been
extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are …

Oxidative phosphorylation (OXPHOS) drives ATP production by mitochondria, which are
dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In …

Despite major improvements in the treatment of patients with diabetes mellitus, many
patients still suffer from progressive diabetic kidney disease. More research is needed to …

Abstract Purpose of Review Diabetic kidney disease (DKD) continues to be the primary
cause of chronic kidney disease in the USA and around the world. The numbers of people …

The underlying mechanisms in the development of diabetic nephropathy are currently
unclear and likely consist of a series of dynamic events from the early to late stages of the …