The IL-1 family in tumorigenesis and antitumor immunity
The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …
Is interleukin‐1 a good or bad 'guy'in tumor immunobiology and immunotherapy?
RN Apte, E Voronov - Immunological reviews, 2008 - Wiley Online Library
The interleukin‐1 (IL‐1) family consists of two major agonistic proteins, IL‐1α and IL‐1β,
which are pleiotropic and affect mainly inflammation, immunity, and hemopoiesis. The IL‐1 …
which are pleiotropic and affect mainly inflammation, immunity, and hemopoiesis. The IL‐1 …
Interleukin-1α
P Rider, Y Carmi, E Voronov, RN Apte - Seminars in immunology, 2013 - Elsevier
Although the IL-1α molecule has long been recognized, information about its distinct role in
various diseases is limited, since most clinical studies have focused on the role of IL-1β …
various diseases is limited, since most clinical studies have focused on the role of IL-1β …
IL-1α processing, signaling and its role in cancer progression
Interleukin-1α (IL-1α) is a major alarmin cytokine which triggers and boosts the inflammatory
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …
[HTML][HTML] The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy
Abstract The interleukin-1 (IL-1) family is one of the first described cytokine families and
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …
Interleukin-1—a major pleiotropic cytokine in tumor–host interactions
RN Apte, E Voronov - Seminars in cancer biology, 2002 - Elsevier
Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1α and IL-1β, that are
pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the …
pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the …
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
K Taniguchi, M Karin - Seminars in immunology, 2014 - Elsevier
Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …
promotion, progression, and metastasis. Cytokines are now recognized as important …
Interleukin-1 in tumor progression, therapy, and prevention
C Garlanda, A Mantovani - Cancer cell, 2021 - cell.com
Summary Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important
role in tumor progression. Based on preclinical models and human genetic associations, we …
role in tumor progression. Based on preclinical models and human genetic associations, we …
Tumor-related interleukins: old validated targets for new anti-cancer drug development
S Setrerrahmane, H Xu - Molecular cancer, 2017 - Springer
In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong
regulation of cancer development and progression by the inflammation which orchestrates …
regulation of cancer development and progression by the inflammation which orchestrates …
Roles of IL-1 in cancer: from tumor progression to resistance to targeted therapies
V Gelfo, D Romaniello, M Mazzeschi, M Sgarzi… - International journal of …, 2020 - mdpi.com
IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …
inflammatory activity. Beyond its biological role as a regulator of the innate immune …