Cisplatin, a simple inorganic compound, has been one of the leading antitumor drugs for
near 30 years. However, cisplatin has several drawbacks such as toxicity and drug …

The impact of cisplatin on cancer chemotherapy cannot be denied. Over the past 20 years,
much effort has been dedicated to discover new platinum‐based anticancer agents that are …

The limitations of cisplatin as an anticancer drug have stimulated the search for other
antitumor-active platinum complexes with improved pharmacological properties. The two …

Platinum-based antitumor drugs have a strong impact on cancer chemotherapy and
constitute a cornerstone for the treatment of various solid tumors such as genitourinary …

Cisplatin is routinely employed for the treatment of testicular, ovarian cancer and head/neck
tumors. Typical doses administrated to patients are 100 mg/day for up to five days. It is …

Cisplatin was discovered to have cytotoxic properties in the 1960s, and by the end of the
1970s it had earned a place as the key ingredient in the systemic treatment of germ cell …

The limitations of cisplatin as an anticancer drug have stimulated the search for other
antitumour-active platinum complexes with improved pharmacological properties. The two …

Platinum compounds, particularly cis-Pt (NH 3) 2 Cl 2, represent a new class of effective
antitumor drugs used clinically in cancer chemotherapy (1). The mechanism of action of …

Biochemical modulation is the manipulation of cellular biochemical pathways by chemical
agents to produce selective enhancement of the efficacy of an antitumor drug. 1 Since the …

Platinum (II) complexes are widely employed in cancer chemotherapy, but their efficacy
against the majority of malignancies is limited. The reasons for this failure are a combination …