This article summarizes my presentation at the Pediatric Hematology‐Oncology Symposium
in honor of Dr. Stephen A. Feig in April 2005. Areas highlighted reflect key topics whose …

Sickle cell anemia (SCA) is both a triumph of modern medicine and a frustrating example of
the slow pace of translational biomedical research. We have known the precise molecular …

Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

Although sickle cell disease has been known for years and many of its manifestations have
been recognized, the “natural history” or clinical course of the disease from early childhood …

[1]. In the intervening years, Dr. Charache has retired from Johns Hopkins University but
remains active at national meetings and with other academic activities. Unfortunately, he …

With the advances in our understanding of the complex mechanisms that come into play in
sickle cell disease (SCD), medical care improves and patients with SCD live longer. It is …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

Sickle cell disease (SCD) is a serious and life-threatening disease that affects approximately
1 in 600 African Americans [1, 2]. In 1910, Herrick described the first patient with SCD, and …

Abstract In 1972, Congress passed the National Sickle Cell Disease Control Act which, for
the first time, provided authority to establish education, information, screening, testing …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …