IL‐22 and inflammation: Leukin'through a glass onion

LA Zenewicz, RA Flavell - European journal of immunology, 2008 - Wiley Online Library
IL‐22 is a Th17 T‐cell‐associated cytokine that is highly expressed during chronic
inflammation. IL‐22 receptor expression is absent on immune cells, but is instead restricted …

IL-11 signaling as a therapeutic target for cancer

TL Putoczki, M Ernst - Immunotherapy, 2015 - Taylor & Francis
IL-11 is a member of the IL-6 family of cytokines. While it was discovered over 20 years ago,
we have very little understanding of the role of IL-11 during normal homeostasis and …

IL-17 signaling: the yin and the yang

N Amatya, AV Garg, SL Gaffen - Trends in immunology, 2017 - cell.com
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …

Interleukin-13 as an important cytokine: A review on its roles in some human diseases

N Seyfizadeh, N Seyfizadeh, T Gharibi… - Acta microbiologica et …, 2015 - akjournals.com
Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to
induce activation responses which contribute to the inflammatory diseases. Genetic …

Interleukin-26: an emerging player in host defense and inflammation

S Tengvall, KF Che, A Lindén - Journal of innate immunity, 2016 - karger.com
The production of interleukin (IL)-26 was initially attributed to T cells, and in particular to
Th17 cells. However, more recent findings indicate IL-26 production in natural killer (NK) …

The IL-12 family of cytokines in infection, inflammation and autoimmune disorders

K Gee, C Guzzo, NF Che Mat, W Ma… - Inflammation & Allergy …, 2009 - ingentaconnect.com
Cytokines are critical coordinators of the immune response necessary for resolving bacterial
and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key …

Interleukin-22: a likely target for treatment of autoimmune diseases

X Yang, SG Zheng - Autoimmunity reviews, 2014 - Elsevier
Abstract Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by
many different types of lymphocytes including both those of the innate and adaptive immune …

The IL-17 family in diseases: from bench to bedside

L Huangfu, R Li, Y Huang, S Wang - Signal Transduction and Targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS)

AM Beebe, DJ Cua, R de Waal Malefyt - Cytokine & growth factor reviews, 2002 - Elsevier
Interleukin-10 (IL-10) is an immunoregulatory cytokine that plays a crucial role in
inflammatory and immune reactions. It has potent anti-inflammatory and immunosuppressive …

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease

SS Iyer, G Cheng - Critical Reviews™ in Immunology, 2012 - dl.begellhouse.com
ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …