Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

The current scenario of naturally occurring indole alkaloids with anticancer potential

J Song, B Zhang, M Li, J Zhang - Fitoterapia, 2023 - Elsevier
Naturally occurring indole alkaloids are ubiquitously present in nature and possess
extensive biological properties and structural diversity. Mechanistically, naturally occurring …

Indole alkaloids with potential anticancer activity

D Xu, Z Xu - Current topics in medicinal chemistry, 2020 - ingentaconnect.com
Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically
active compounds. Indole alkaloids have the potential to exert anticancer activity via various …

Mechanisms and therapeutic implications of cell death induction by indole compounds

A Ahmad, WA Sakr, KMW Rahman - Cancers, 2011 - mdpi.com
Indole compounds, obtained from cruciferous vegetables, are well-known for their anti-
cancer properties. In particular, indole-3-carbinol (I3C) and its dimeric product, 3, 3 …

[HTML][HTML] Advances in indole-containing alkaloids as potential anticancer agents by regulating autophagy

ML Luo, W Huang, HP Zhu, C Peng, Q Zhao… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of death worldwide, and cancer development is often associated
with disturbances in the autophagy process. Autophagy is a catabolic process involved in …

Indole alkaloids, synthetic dimers and hybrids with potential in vivo anticancer activity

F Song, Y Bian, J Liu, Z Li, L Zhao… - Current Topics in …, 2021 - ingentaconnect.com
Indole, a heterocyclic organic compound, is one of the most promising heterocycles found in
natural and synthetic sources since its derivatives possess fascinating structural diversity …

[PDF][PDF] Indoles as anti-cancer agents. Adv Mod Oncol Res 2015; 1 (1): 20–35

MT El Sayed, NA Hamdy, DA Osman - 2011 - scholar.archive.org
Indoles are natural products which are well known for its anti-cancer activity due to its ability
to induce cell death for many cancer cell lines. This review addresses indoles as natural …

Targeting regulated cell death (RCD) with small-molecule compounds in cancer therapy: A revisited review of apoptosis, autophagy-dependent cell death and …

W Liu, W Jin, S Zhu, Y Chen, B Liu - Drug Discovery Today, 2022 - Elsevier
Evasion of regulated cell death (RCD), mainly referring to apoptosis, autophagy-dependent
cell death, necroptosis, and other subroutines, is one of the well-established hallmarks of …

Targeting programmed cell death using small‐molecule compounds to improve potential cancer therapy

B Ke, M Tian, J Li, B Liu, G He - Medicinal research reviews, 2016 - Wiley Online Library
Evasion of cell death is one of the hallmarks of cancer cells, beginning with long‐
established apoptosis and extending to other new forms of cell death. An elaboration of cell …

Targeting regulated cell death with pharmacological small molecules: An update on autophagy-dependent cell death, ferroptosis, and necroptosis in cancer …

J Wu, J Ye, Q Xie, B Liu, M Liu - Journal of Medicinal Chemistry, 2022 - ACS Publications
Regulated cell death is a widely attractive subject among the topics of cancer therapy and
has gained some advances for discovery of targeted anticancer drugs. In the past decade …