Molecular mechanisms and novel therapeutic approaches to rhabdomyolysis-induced acute kidney injury

N Panizo, A Rubio-Navarro… - Kidney and Blood …, 2015 - karger.com
Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to
acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including …

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure

O Boutaud, LJ Roberts II - Free Radical Biology and Medicine, 2011 - Elsevier
Rhabdomyolysis-induced renal failure represents up to 15% of all cases of acute renal
failure. Many studies over the past 4 decades have demonstrated that accumulation of …

Pathogenesis and treatment of renal dysfunction in rhabdomyolysis

S Holt, K Moore - Intensive care medicine, 2001 - Springer
Rhabdomyolysis is a major cause of acute renal failure, and recent experimental data have
provided a better understanding of the pathophysiology of the renal dysfunction. Renal …

Rhabdomyolysis and acute kidney injury

X Bosch, E Poch, JM Grau - New England Journal of Medicine, 2009 - Mass Medical Soc
The causes of acute rhabdomyolysis include trauma, drugs, toxins, and certain infections.
Acute kidney injury is a dangerous complication of severe rhabdomyolysis. This review …

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

K Okubo, M Kurosawa, M Kamiya, Y Urano, A Suzuki… - Nature medicine, 2018 - nature.com
Rhabdomyolysis is a serious syndrome caused by skeletal muscle injury and the
subsequent release of breakdown products from damaged muscle cells into systemic …

[HTML][HTML] Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review

N Petejova, A Martinek - Critical Care, 2014 - Springer
Rhabdomyolysis, a clinical syndrome caused by damage to skeletal muscle and release of
its breakdown products into the circulation, can be followed by acute kidney injury (AKI) as a …

[HTML][HTML] Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke

Y Luan, E Huang, J Huang, Z Yang, Z Zhou… - Journal of translational …, 2023 - degruyter.com
Abstract Background and Objectives Myoglobin released by rhabdomyolysis (RM) is
considered to be involved in pathogenesis of kidney disease caused by crush injury, but …

Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis

I Boudhabhay, V Poillerat, A Grunenwald, C Torset… - Kidney International, 2021 - Elsevier
Rhabdomyolysis is a life-threatening condition caused by skeletal muscle damage with
acute kidney injury being the main complication dramatically worsening the prognosis …

Allopurinol attenuates rhabdomyolysis-associated acute kidney injury: Renal and muscular protection

PHF Gois, D Canale, RA Volpini, D Ferreira… - Free Radical Biology …, 2016 - Elsevier
Background Acute kidney injury (AKI) is the most severe complication of rhabdomyolysis.
Allopurinol (Allo), a xanthine oxidase inhibitor, has been in the spotlight in the last decade …

Rhabdomyolysis

JL Zimmerman, MC Shen - Chest, 2013 - Elsevier
Rhabdomyolysis is a well-known clinical syndrome of muscle injury associated with
myoglobinuria, electrolyte abnormalities, and often acute kidney injury (AKI). The …