The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis

P Anagnostis, VG Athyros, K Tziomalos… - The Journal of …, 2009 - academic.oup.com
Context: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities that
increase the risk for type 2 diabetes mellitus and vascular disease. The common …

Role of stress in the pathogenesis of the metabolic syndrome

R Rosmond - Psychoneuroendocrinology, 2005 - Elsevier
Excess body fat, obesity, is one of the most common disorders in clinical practice. In
addition, there is a clustering of several risk factors with obesity, including hypertension …

Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity

E Rask, BR Walker, S Söderberg… - The Journal of …, 2002 - academic.oup.com
Cushing's syndrome and the metabolic syndrome share clinical similarities. Reports of
alterations in the hypothalamic-pituitary-adrenal (HPA) axis are inconsistent, however, in the …

[HTML][HTML] Cortisol: the villain in metabolic syndrome?

S Paredes, L Ribeiro - Revista da Associação Médica Brasileira, 2014 - SciELO Brasil
Objective This article reviews the state of the art regarding the association between
glucocorticoid actions and both obesity and insulin resistance, two main features of the …

The role of stress and the hypothalamic–pituitary–adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes

GP Chrousos - International Journal of Obesity, 2000 - nature.com
The stress system coordinates the adaptive response of the organism to real or perceived
stressors. The main components of the stress system are the corticotropin-releasing …

Cortisol, obesity, and the metabolic syndrome: A cross‐sectional study of obese subjects and review of the literature

SB Abraham, D Rubino, N Sinaii, S Ramsey… - …, 2013 - Wiley Online Library
Objective: Circulating cortisol and psychosocial stress may contribute to the pathogenesis of
obesity and metabolic syndrome (MS). To evaluate these relationships, a cross‐sectional …

Association between the metabolic syndrome and serum cortisol in overweight Latino youth

MJ Weigensberg, CM Toledo-Corral… - The Journal of Clinical …, 2008 - academic.oup.com
Objective: The purpose of this report is to investigate the associations between metabolic
syndrome (MS) and levels of morning serum cortisol in a cohort of overweight Latino youth …

The role of glucocorticoid action in the pathophysiology of the metabolic syndrome

M Wang - Nutrition & metabolism, 2005 - Springer
Glucocorticoids are stress hormones that modulate a large number of physiological actions
involved in metabolic, inflammatory, cardiovascular and behavioral processes. The …

Cortisol metabolism in human obesity: impaired cortisone→ cortisol conversion in subjects with central adiposity

PM Stewart, A Boulton, S Kumar… - The Journal of …, 1999 - academic.oup.com
For a given body mass index (BMI), mortality is higher in patients with central compared to
generalized obesity. Glucocorticoids play an important role in determining body fat …

Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors

RM Reynolds, BR Walker, HE Syddall… - The Journal of …, 2001 - academic.oup.com
It has been suggested that increased activity of the hypothalamic-pituitary-adrenal axis may
link low birth weight with subsequent development of cardiovascular risk factors and …