Synaptic functional disturbances with concomitant synapse loss represent central
pathological hallmarks of Alzheimer's disease. Excessive accumulation of cytotoxic amyloid …

Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Cognitive decline and disease progression in different neurodegenerative diseases typically
involves synaptic dysfunction preceding the neuronal loss. The synaptic dysfunction is …

Complement is involved in developmental synaptic pruning and pathological synapse loss
in Alzheimer's disease. It is posited that C1 binding initiates complement activation on …

Synaptic dysfunction is an early event in Alzheimer's disease patients and has also been
detected in transgenic mouse models. In the present study, we analyzed proteomic changes …

The innate immune system plays an integral role in the brain. Synaptic pruning, a
fundamental process in developmental circuit refinement, is partially mediated by …

Background Synaptic dysfunction occurs early in Alzheimer's disease (AD) and is
recognized to be a primary pathological target for treatment. Synapse degeneration or …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Synaptic proteomes have evolved a rich and complex diversity to allow the exquisite control
of neuronal communication and information transfer. It is therefore not surprising that many …