Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy
C Wellbrock, I Arozarena - Pigment cell & melanoma research, 2015 - Wiley Online Library
Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …
MITF in melanoma: mechanisms behind its expression and activity
ML Hartman, M Czyz - Cellular and Molecular Life Sciences, 2015 - Springer
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …
MITF: master regulator of melanocyte development and melanoma oncogene
C Levy, M Khaled, DE Fisher - Trends in molecular medicine, 2006 - cell.com
Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …
melanocyte development, function and survival by modulating various differentiation and …
Molecular network associated with MITF in skin melanoma development and progression
Various environmental and genetic factors affect the development and progression of skin
cancers including melanoma. Melanoma development is initially triggered by environmental …
cancers including melanoma. Melanoma development is initially triggered by environmental …
MITF in normal melanocytes, cutaneous and uveal melanoma: a delicate balance
MC Gelmi, LE Houtzagers, T Strub, I Krossa… - International journal of …, 2022 - mdpi.com
Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …
melanogenesis and melanocyte development. Although it has been studied extensively in …
[HTML][HTML] Pro-survival role of MITF in melanoma
ML Hartman, M Czyz - Journal of Investigative Dermatology, 2015 - Elsevier
Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …
[HTML][HTML] A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo
JA Lister, A Capper, Z Zeng, ME Mathers… - Journal of Investigative …, 2014 - Elsevier
The microphthalmia-associated transcription factor (MITF) is the “master melanocyte
transcription factor” with a complex role in melanoma. MITF protein levels vary between and …
transcription factor” with a complex role in melanoma. MITF protein levels vary between and …
Novel MITF targets identified using a two‐step DNA microarray strategy
KS Hoek, NC Schlegel, OM Eichhoff… - Pigment cell & …, 2008 - Wiley Online Library
Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent
advances in our understanding of the disease at the molecular level have indicated that it …
advances in our understanding of the disease at the molecular level have indicated that it …
Microphthalmia-associated transcription factor gene amplification in metastatic melanoma is a prognostic marker for patient survival, but not a predictive marker for …
Purpose: The microphthalmia-associated transcription factor (MITF) is regarded as a key
oncogene of the melanocytic lineage since it was detected by a genome-wide analysis to be …
oncogene of the melanocytic lineage since it was detected by a genome-wide analysis to be …
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF
C Wellbrock, S Rana, H Paterson, H Pickersgill… - PloS one, 2008 - journals.plos.org
The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-
type specific functions in melanocytic cells. MITF is essential for the survival of pigmented …
type specific functions in melanocytic cells. MITF is essential for the survival of pigmented …