Molecular targeted therapy in the treatment of advanced stage non‐small cell lung cancer (NSCLC)

N Barr Kumarakulasinghe, N Zanwijk, RA Soo - Respirology, 2015 - Wiley Online Library
Historically, patients with advanced stage non‐small cell lung cancer (NSCLC) were treated
with chemotherapy alone, but a therapeutic plateau has been reached. Advances in the …

Second-line treatment of non-small cell lung cancer: new developments for tumours not harbouring targetable oncogenic driver mutations

PC Barnfield, PM Ellis - Drugs, 2016 - Springer
Platinum-based doublet chemotherapy with or without bevacizumab is the standard of care
for the initial management of advanced and metastatic non-small cell lung cancer (NSCLC) …

[HTML][HTML] Novel therapeutic targets in non-small cell lung cancer

F Janku, I Garrido-Laguna, LB Petruzelka… - Journal of Thoracic …, 2011 - Elsevier
The development of personalized medicine with a focus on novel targeted therapies has
supplanted the one-size-fits-all approach to the treatment of many cancers, including non …

Individualized therapy in non-small-cell lung cancer: future versus current clinical practice

R Perez-Soler - Oncogene, 2009 - nature.com
Despite advances in the management of non-small-cell lung cancer (NSCLC), including the
introduction of targeted therapies such as epidermal growth factor receptor tyrosine kinase …

Precision management of advanced non–small cell lung cancer

CY Yang, JCH Yang, PC Yang - Annual review of medicine, 2020 - annualreviews.org
The rapid evolution of treatment for advanced lung cancer is a story of how scientists have
struggled to move from nonselective cytotoxic chemotherapy to personalized precision …

[HTML][HTML] Should progression-free survival be the primary measure of efficacy for advanced NSCLC therapy?

JC Soria, C Massard, T Le Chevalier - Annals of Oncology, 2010 - Elsevier
Non-small-cell lung cancer (NSCLC) is a leading cause of malignancy-related mortality in
the Western world. Despite advances in early detection and standard treatment, NSCLC is …

[HTML][HTML] Historical evolution of second-line therapy in non-small cell lung cancer

C Lazzari, A Bulotta, M Ducceschi, MG Vigano… - Frontiers in …, 2017 - frontiersin.org
Innovative therapeutic agents have significantly improved outcome with an acceptable
safety profile in a substantial proportion of non-small cell lung cancer (NSCLC) patients, who …

Novel targeted therapies for advanced non-small lung cancer

O Abughanimeh, A Kaur, B El Osta, AK Ganti - Seminars in Oncology, 2022 - Elsevier
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer accounting for
almost 80%–85% of all lung cancer cases. Unfortunately, more than half of the patients will …

[HTML][HTML] Breakthrough in targeted therapy for non-small cell lung cancer

Z Ye, Y Huang, J Ke, X Zhu, S Leng, H Luo - Biomedicine & …, 2021 - Elsevier
Non-small cell lung cancer (NSCLC) remains by far the single most common malignancy of
lung cancer which causes more and more mortality in recent years. NSCLC accounts for …

Targeted therapies in combination with chemotherapy in non–small cell lung cancer

DH Johnson - Clinical cancer research, 2006 - AACR
With rare exceptions, attempts to combine so-called targeted agents with standard cytotoxic
chemotherapy in advanced non–small cell lung cancer have yielded disappointing results …