Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor
microenvironment (TME) and influence cancer hallmarks, but without systematic …

While regulatory T (Treg) cells are traditionally viewed as professional suppressors of
antigen presenting cells and effector T cells in both autoimmunity and cancer, recent …

There is a dearth of knowledge about the pathogenesis of premalignant lung lesions,
especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the …

Background Small cell lung cancer (SCLC) is the most deadly and aggressive type of
primary lung cancer, with the 5-year survival rate lower than 5%. The FDA has approved …

Background Cancer stem cells (CSCs) play vital roles in lung adenocarcinoma (LUAD)
recurrence, metastasis, and drug resistance. Cuproptosis has provided a novel insight into …

Mitochondrial transcription factor A (TFAM) is essential for the replication, transcription and
maintenance of mitochondrial DNA (mtDNA). The role of TFAM in non-small cell lung cancer …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death. This study
aimed to examine the roles of DHRS4-AS1/miR-224-3p signaling in the cancer cell …

Recent studies suggest that lung cancer stem cells (CSCs) may play major roles in lung
cancer. Therefore, identification of lung CSC drivers may provide promising targets for lung …

Epithelial-mesenchymal transition (EMT) and ferroptosis are two important processes in
biology. In tumor cells, they are intimately linked. We used single-cell RNA sequencing to …

Adenocarcinoma accounts for more than 40% of lung malignancy, and microscopic
pathology evaluation is indispensable for its diagnosis. However, how histopathology …