Patients with non–small cell lung cancer (NSCLC) with malignant pleural effusion (MPE)
have a short median survival time and increased regulatory T cells (Treg). However, it is …

Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …

Ferroptosis is a regulated cell death process initiated by iron-dependent phospholipid
peroxidation and is mainly suppressed by GPX4-dependent and FSP1-dependent …

Tertiary lymphoid structures (TLSs) in tumor tissues facilitate immune cell trafficking and
cytotoxicity, which benefits survival and favorable responses in immune therapy. Here, we …

Long non-coding RNAs (lncRNAs) regulate numerous biological processes involved in both
development and carcinogenesis. Hippo-YAP/TAZ signaling, a critical pathway responsible …

Lung adenocarcinoma (LUAD) is the main histological type of lung cancer, which is the
leading cause of cancer-related deaths. Long non-coding RNAs (lncRNAs) were recently …

Macrophages are heterogeneous cells that play multifaceted roles in cancer progression
and metastasis. However, the phenotypic diversity of tumor-associated macrophages …

Lung adenocarcinoma (LUAD) is one of the leading fatal malignancy with high morbidity
and mortality worldwide. However, due to its complicated mechanism and lack of effective …

Homing of CD8+ T lymphocytes to the tumor microenvironment is an important step for
mounting a robust antitumor immune response. TGFβ is responsible for CD103 (αEβ7) …

Tumor-initiating stem cells (TSCs) are critical for drug resistance and immune escape.
However, the mutual regulations between TSC and tumor microenvironment (TME) remain …