Gene therapy targeting nuclear factor-κB: towards clinical application in inflammatory diseases and cancer
SW Tas, MJBM Vervoordeldonk… - Current gene therapy, 2009 - ingentaconnect.com
Nuclear factor (NF)-κB is regarded as one of the most important transcription factors and
plays an essential role in the transcriptional activation of pro-inflammatory cytokines, cell …
plays an essential role in the transcriptional activation of pro-inflammatory cytokines, cell …
NF-κB as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of IκBα cDNA
SS Makarov, WN Johnston, JC Olsen, JM Watson… - Gene therapy, 1997 - nature.com
One of the most challenging issues of anti-inflammatory gene therapy is the complexity of
inflammatory pathways. Transcription factor NF-κB plays a pivotal role in activation of …
inflammatory pathways. Transcription factor NF-κB plays a pivotal role in activation of …
NF-κB cellular and molecular regulatory mechanisms and pathways: therapeutic pattern or pseudoregulation?
JJ Haddad, NE Abdel-Karim - Cellular immunology, 2011 - Elsevier
As fascinating a molecule as it can potentially get, nuclear factor-κB (NF-κB), a regulatory
transcription factor, is as intriguing. NF-κB is a dimeric complex that controls the transcription …
transcription factor, is as intriguing. NF-κB is a dimeric complex that controls the transcription …
Molecular pathways: the balance between cancer and the immune system challenges the therapeutic specificity of targeting nuclear factor-κB signaling for cancer …
KP Zeligs, MK Neuman, CM Annunziata - Clinical Cancer Research, 2016 - AACR
The NF-κB signaling pathway is a complex network linking extracellular stimuli to cell
survival and proliferation. Cytoplasmic signaling to activate NF-κB can occur as part of the …
survival and proliferation. Cytoplasmic signaling to activate NF-κB can occur as part of the …
NF-κB inhibitors for the treatment of inflammatory diseases and cancer
MA Calzado, S Bacher… - Current medicinal …, 2007 - ingentaconnect.com
The NF-κB/Rel signaling system is a paradigm for gene activation in response to
inflammatory and menacing stimuli. Given the growing body of evidence showing an …
inflammatory and menacing stimuli. Given the growing body of evidence showing an …
Targeting NF-κB: a promising molecular therapy in inflammatory arthritis
JA Roman-Blas, SA Jimenez - International reviews of immunology, 2008 - Taylor & Francis
The nuclear factor-κ B family of transcription factors is intimately involved in the regulation of
the inflammatory responses that play a fundamental role in the damage of articular tissues …
the inflammatory responses that play a fundamental role in the damage of articular tissues …
Unlocking the NF-κB conundrum: embracing complexity to achieve specificity
F Begalli, J Bennett, D Capece, D Verzella, D D'Andrea… - Biomedicines, 2017 - mdpi.com
Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating
regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB …
regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB …
NF-κB as a target for cancer therapy
D Melisi, PJ Chiao - Expert opinion on therapeutic targets, 2007 - Taylor & Francis
NF-κB transcription factors and the signaling pathways that activate them play a critical role
in cancer development, progression and therapy, and recently have become a focal point for …
in cancer development, progression and therapy, and recently have become a focal point for …
NF-κB: arresting a major culprit in cancer
B Haefner - Drug Discovery Today, 2002 - Elsevier
Nuclear factor-κB (NF-κB) has long been known to play a central role in the immune system
by regulating the expression of key genes. Moreover, activation of this transcription factor …
by regulating the expression of key genes. Moreover, activation of this transcription factor …
A critical transcription factor NF-κB as a cancer therapeutic target and its inhibitors as cancer treatment options
Nuclear Factor-Κappa B (NF-ΚB) is a family of critical transcription factors of the
inflammatory pathway and plays an imperative role in the progression of various cancers …
inflammatory pathway and plays an imperative role in the progression of various cancers …
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