Polymorphisms in the apolipoprotein (a) gene and their relationship to allele size and plasma lipoprotein (a) concentration

LH Puckey, RM Lawn, BL Knight - Human molecular genetics, 1997 - academic.oup.com
Genotypes at five previously described polymorphic sites at the apolipoprotein (a) gene
locus have been determined for the members of 27 families as well as for unrelated white …

Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.

JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
Apolipoprotein (a)[apo (a)], an apolipoprotein unique to lipoprotein (a)[Lp (a)], is highly
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp (a) in plasma

V Mooser, FP Mancini, S Bopp… - Human molecular …, 1995 - academic.oup.com
Most of the Interindividual variations in plasma levels of lipoprotein (a)[Lp (a)] can be
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

A pentanucleotide repeat polymorphism in the 5'control region of the apolipoprotein (a) gene is associated with lipoprotein (a) plasma concentrations in Caucasians.

M Trommsdorff, S Köchl, A Lingenhel… - The Journal of …, 1995 - Am Soc Clin Investig
The enormous interindividual variation in the plasma concentrations of the atherogenic
lipoprotein (a)[Lp (a)] is almost entirely controlled by the apo (a) locus on chromosome 6q26 …

Apolipoprotein (a) polymorphism and its association with plasma lipoprotein (a) levels: a north Indian study.

S Vasisht, R Gulati, LM Srivastava, R Narang… - Indian Heart …, 2000 - europepmc.org
Elevated levels of lipoprotein (a) has been regarded as an independent risk factor for
coronary, peripheral and cerebral atherosclerosis. The enormous intra-personal variation in …

Polymorphic forms of human apolipoprotein [a]: inheritance and relationship of their molecular weights to plasma levels of lipoprotein [a].

JW Gaubatz, KI Ghanem, J Guevara, ML Nava… - Journal of Lipid …, 1990 - ASBMB
The plasma concentration of human lipoprotein [a], Lp [a], is highly correlated with coronary
artery disease. The protein moiety of Lp [a], apoLp [a], consists of two apoproteins, apo [a] …

Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.

C Lackner, E Boerwinkle, CC Leffert… - The Journal of …, 1991 - Am Soc Clin Investig
Lipoprotein (a)[Lp (a)] is a cholesterol-rich lipoprotein that is distinguished by its content of a
glycoprotein called apolipoprotein (a)[apo (a)]. Apo (a) varies in size among individuals …

Variation in the size of human apolipoprotein (a) is due to a hypervariable region in the gene

G Lindahl, E Gersdorf, HJ Menzel, M Seed… - Human genetics, 1990 - Springer
We have investigated whether the size heterogeneity of the human apolipoprotein (a)[apo
(a)] is due to differences in the number of plasminogen kringle 4-like repeat units present in …