Grhl2 is required in nonneural tissues for neural progenitor survival and forebrain development
Grainyhead‐like genes are part of a highly conserved gene family that play a number of
roles in ectoderm development and maintenance in mammals. Here we identify a novel …
roles in ectoderm development and maintenance in mammals. Here we identify a novel …
Grainyhead‐like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety‐like behaviors in aged mice
S Dworkin, A Auden, DD Partridge… - Developmental …, 2017 - Wiley Online Library
The highly conserved Grainyhead‐like (Grhl) family of transcription factors, comprising three
members in vertebrates (Grhl1‐3), play critical regulatory roles during embryonic …
members in vertebrates (Grhl1‐3), play critical regulatory roles during embryonic …
Delineating the roles of Grhl2 in craniofacial development through tissue‐specific conditional deletion and epistasis approaches in mouse
M de Vries, HG Owens, MR Carpinelli… - Developmental …, 2021 - Wiley Online Library
Abstract Background The highly conserved Grainyhead‐like (Grhl) family of transcription
factors play critical roles in the development of the neural tube and craniofacial skeleton. In …
factors play critical roles in the development of the neural tube and craniofacial skeleton. In …
Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice
SCP De Castro, P Gustavsson… - Human molecular …, 2018 - academic.oup.com
The genetic basis of human neural tube defects (NTDs), such as anencephaly and spina
bifida (SB), is complex and heterogeneous. Grainyhead-like genes represent candidates for …
bifida (SB), is complex and heterogeneous. Grainyhead-like genes represent candidates for …
Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic …
SJ Goldie, BD Arhatari, P Anderson, A Auden… - BMC developmental …, 2016 - Springer
Background Increased apposition of the frontal and parietal bones of the skull during
embryogenesis may be a risk factor for the subsequent development of premature skull …
embryogenesis may be a risk factor for the subsequent development of premature skull …
Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development
A Auden, J Caddy, T Wilanowski, SB Ting… - Gene expression …, 2006 - Elsevier
The Drosophila transcription factor Grainyhead (grh) is expressed in ectoderm-derived
tissues where it regulates several key developmental events including cuticle formation …
tissues where it regulates several key developmental events including cuticle formation …
Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure
HJ Ray, LA Niswander - Development, 2016 - journals.biologists.com
The transcription factor grainyhead-like 2 (GRHL2) is expressed in non-neural ectoderm
(NNE) and Grhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice …
(NNE) and Grhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice …
Grainyhead genes and mammalian neural tube closure
P Gustavsson, AJ Copp… - Birth Defects Research …, 2008 - Wiley Online Library
BACKGROUND: Grainyhead genes encode a family of transcription factors that are well
conserved from fly to human. The three mammalian homologues, Grainyhead‐like‐1,‐2, and …
conserved from fly to human. The three mammalian homologues, Grainyhead‐like‐1,‐2, and …
Loss of Grhl3 is correlated with altered cellular protrusions in the non‐neural ectoderm during neural tube closure
E Jaffe, L Niswander - Developmental Dynamics, 2021 - Wiley Online Library
Abstract Background The transcription factor Grainyhead‐like 3 (GRHL3) has multiple roles
in a variety of tissues during development including epithelial patterning and actin …
in a variety of tissues during development including epithelial patterning and actin …
Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse
M de Vries, M Carpinelli, E Rutland, A Hatzipantelis… - Developmental …, 2020 - Elsevier
The highly-conserved Grainyhead-like (Grhl) transcription factors are critical regulators of
embryogenesis that regulate cellular survival, proliferation, migration and epithelial integrity …
embryogenesis that regulate cellular survival, proliferation, migration and epithelial integrity …