Importance Evolutionary medicine may provide insights into human physiology and
pathophysiology, including tumor biology. Objective To identify mechanisms for cancer …

A major constraint on the evolution of large body sizes in animals is an increased risk of
developing cancer. There is no correlation, however, between body size and cancer risk …

Disease susceptibility and resistance are important factors for the conservation of
endangered species, including elephants. We analyzed pathology data from 26 zoos and …

The risk of developing cancer is correlated with body size and lifespan within species.
Between species, however, there is no correlation between cancer and either body size or …

Large-bodied organisms have more cells that can potentially turn cancerous than small-
bodied organisms, imposing an increased risk of developing cancer. This expectation …

Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …

Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Background Cancer is a major medical problem in modern societies. However, the
incidence of this disease in non-human primates is very low. To study whether genetic …

Background Cancer is a common diagnosis in many mammalian species, yet they vary in
their vulnerability to cancer. The factors driving this variation are unknown, but life history …

Apoptosis triggered by p53 upon DNA damage secures removal of cells with compromised
genomes, and is thought to prevent tumorigenesis. In contrast, we provide evidence that p53 …