Hepatic phenotype of liver fatty acid binding protein gene-ablated mice

GG Martin, BP Atshaves, H Huang… - American Journal …, 2009 - journals.physiology.org
Although the function of liver fatty acid binding protein in hepatic fatty acid metabolism has
been extensively studied, its potential role in hepatic cholesterol homeostasis is less clear …

Liver fatty acid binding protein gene ablation potentiates hepatic cholesterol accumulation in cholesterol-fed female mice

GG Martin, BP Atshaves, AL McIntosh… - American Journal …, 2006 - journals.physiology.org
Although liver fatty acid binding protein (L-FABP) is postulated to influence cholesterol
homeostasis, the physiological significance of this hypothesis remains to be resolved. This …

Liver fatty acid-binding protein gene ablation inhibits branched-chain fatty acid metabolism in cultured primary hepatocytes

BP Atshaves, AM McIntosh, OI Lyuksyutova… - Journal of Biological …, 2004 - ASBMB
Whereas the role of liver fatty acid-binding protein (L-FABP) in the uptake, transport,
mitochondrial oxidation, and esterification of normal straight-chain fatty acids has been …

Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene

EP Newberry, Y Xie, S Kennedy, X Han… - Journal of Biological …, 2003 - ASBMB
Liver fatty acid-binding protein (L-Fabp) is an abundant cytosolic lipid-binding protein with
broad substrate specificity, expressed in mammalian enterocytes and hepatocytes. We have …

Liver fatty acid-binding protein and obesity

BP Atshaves, GG Martin, HA Hostetler… - The Journal of nutritional …, 2010 - Elsevier
While low levels of unesterified long chain fatty acids (LCFAs) are normal metabolic
intermediates of dietary and endogenous fat, LCFAs are also potent regulators of key …

Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice

EP Newberry, SM Kennedy, Y Xie, J Luo… - Molecular and cellular …, 2009 - Springer
Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and
hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids …

L-FABP T94A decreased fatty acid uptake and altered hepatic triglyceride and cholesterol accumulation in Chang liver cells stably transfected with L-FABP

N Gao, X Qu, J Yan, Q Huang, HY Yuan… - Molecular and cellular …, 2010 - Springer
Liver fatty acid-binding protein (L-FABP, FABP1) is a highly conserved key factor in lipid
metabolism. This study was undertaken to verify whether the T94A mutation in the L-FABP …

Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver

LB Agellon, L Drozdowski, L Li, C Iordache… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Mice lacking I-FABP (encoded by the Fabp2 gene) exhibit a gender dimorphic response to a
high fat/cholesterol diet challenge characterized by hepatomegaly in male I-FABP-deficient …

Liver fatty acid binding protein gene ablation enhances age-dependent weight gain in male mice

GG Martin, BP Atshaves, AL McIntosh… - Molecular and cellular …, 2009 - Springer
Although studies performed in vitro and with transfected cells in culture suggest a role for
liver fatty acid binding protein (L-FABP) in regulating fatty acid oxidation and fat deposition …

Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene

GG Martin, H Danneberg, LS Kumar… - Journal of Biological …, 2003 - ASBMB
Although liver fatty acid-binding protein (L-FABP) is an important binding site for various
hydrophobic ligands in hepatocytes, its in vivo significance is not understood. We have …