Objective: To describe the prevalence and natural history of augmented renal clearance in a
cohort of recently admitted critically ill patients with normal plasma creatinine concentrations …

Critically ill patients can display markedly abnormal physiological parameters compared
with those in ward-based or ambulatory settings. As a function of both the underlying …

BACKGROUND: Augmented renal clearance in critically ill patients can result in
underdosing of life-saving drugs, potentially leading to therapeutic failure. To detect this …

Augmented renal clearance (ARC) has been reported in approximately 30–65% of patients
in the intensive care unit (ICU) despite the presence of a normal serum creatinine …

Augmented renal clearance (ARC) is a manifestation of enhanced renal function seen in
critically ill patients. The use of regular unadjusted doses of renally eliminated drugs in …

Introduction Improved methods to optimize drug dosing in the critically ill are urgently
needed. Traditional prescribing culture involves recognition of factors that mandate dose …

Results In total, 700 cases were identified, with a 66% incidence of AKI. In 241 patients
without AKI, creatinine was significantly lower (P< 0.001) at hospital discharge than …

Many critically ill patients display a supraphysiological renal function with enhanced renal
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …

Objective: Malnutrition and low muscle mass reduce the ability of patients to fight critical
illness. Low serum creatinine is a better surrogate marker of low muscle mass than a low …

Background In ICU patients with normal serum creatinine (SCr), a state of increased renal
drug excretion has been described (creatinine clearance≥ 130 ml/min/1.73 m 2), and …