Neural tube defects (NTDs) are congenital abnormalities in the central nervous system. The
exact etiology of NTDs is still not determined, but several genetic and epigenetic factors …

Background Neural Tube Defects (NTDs) are among the most prevalent and most severe
congenital malformations worldwide. Polymorphisms in key genes involving the folate …

Neural tube defects (NTDs) are among the commonest human birth defects, affecting around
1 per 1,000 births [Copp et al., 2003]. A genetic basis for NTDs is implicated based on the …

Epidemiological studies have evaluated the association between maternal
methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase …

Aims We investigated the hypothesis that there are interactions between SNPs in folate
metabolism pathway genes and environmental risk factors to the etiology of neural tube …

Background Worldwide, Neural tube defects (NTDs) are considered as major clinical
problems imposing a huge socio‐economic burden for both affected individuals and their …

Objectives Neural tube defect (NTD) is a common disease among neonates with multiplex
symptom and complex origins, and the exact mechanism of NTD has not been definitely …

The reduced folate carrier (RFC1) plays a crucial role in mediating folate delivery into a
variety of cells. RFC1 polymorphism (A80G) has been reported to be associated with …

In this paper, we trace the history of current research into the genetic and biochemical
mechanisms that underlie folate‐preventable neural tube defects (NTDs). The inspired …

Abstract Purpose Neural tube defects (NTDs) are one of the most prevalent and the most
severe congenital malformations worldwide. Studies have confirmed that folic acid …