The sharp increase in obesity prevalence worldwide is mainly attributable to changes in
physical activity and eating behavior but the metabolic and clinical impacts of these …

Aims/hypothesis Metabolic disorders are commonly investigated using knockout and
transgenic mouse models. A variety of mouse strains have been used for this purpose …

Obesity is routinely considered as a single disease state, which drives a “one-size-fits-all”
approach to treatment. We recently convened the first annual University of North Carolina …

When is a calorie not just a calorie? In the current issue of Nature Metabolism, Roy et al. use
recombinant inbred strains of mice to investigate the role of genetic background in the …

Defined as chronic excessive accumulation of adiposity, obesity results from long-term
imbalance between energy intake and expenditure. The mechanisms behind how caloric …

Barrington et al. examined the effect of four human diets (American, Mediterranean,
Japanese, and Maasai/ketogenic) on metabolic health across four mouse... The incidence of …

High energy intake and, specifically, high dietary fat intake challenge the mammalian
metabolism and correlate with many metabolic disorders such as obesity and diabetes …

Maintaining a healthy body weight requires an exquisite balance between energy intake
and energy expenditure. To understand the genetic and environmental factors that …

Background: Metabolic disorders are commonly investigated using knockout and transgenic
mouse models on the C57BL/6N genetic background due to its genetic susceptibility to the …

The development of the metabolic syndrome in an increasing percentage of the populations
of Western societies, particularly in the United States, requires valid models for establishing …