Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type
2 diabetes. The molecular mechanisms that mediate this response occur across many highly …

Prevalence and health consequences of obesity differ between men and women. Yet, most
preclinical studies investigating the etiology of obesity have, to date, been conducted in …

Highly inbred C57BL/6 mice show wide variation in their degree of insulin resistance in
response to diet-induced obesity even though they are almost genetically identical. Here we …

Obesity is a growing societal scourge. Recent studies have uncovered that paternal
excessive weight induced by an unbalanced diet affects the metabolic health of offspring …

Elucidating the mechanism underlying the transmission of metabolic disease to subsequent
generations requires robust preclinical mouse breeding strategies. Western diets rich in fat …

Obesity has reached epidemic proportions and is recognised as a significant global health
problem. Increased food intake and decreased physical activity are traditionally to blame for …

Profound changes in macronutrient composition of food have taken place since the
agricultural revolution, leading to a higher dietary intake of carbohydrates at the expense of …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

Diet is a critical element determining human health and diseases, and unbalanced food
habits are major risk factors for the development of obesity and related metabolic disorders …

Obesity is the result of excess energy intake relative to expenditure, however little is known
about why some individuals are more prone to weight gain than others. Inbred strains of …