Melatonin is an effector of the diurnal clock on pancreatic islets. The membrane receptor‐
transmitted inhibitory influence of melatonin on insulin secretion is well established and …

Recent investigations of our group established that melatonin modulates hormone secretion
of pancreatic islets via melatonin receptor types MT 1 and MT 2. Expression of MT 1 and MT …

Melatonin is known to inhibit insulin secretion from rodent β‐cells through interactions with
cell‐surface MT1 and/or MT2 receptors, but the function of this hormone in human islets of …

Recent investigations have demonstrated an influence of melatonin on insulin secretion in
pancreatic β‐cells. The effects are receptor‐mediated via two parallel signaling pathways …

Recent functional, autoradiographic, and molecular investigations have shown that the
pineal secretory product melatonin reduces the forskolin‐stimulated insulin secretion from …

Previous results demonstrated that melatonin inhibits cAMP production and stimulates IP3
liberation in rat insulinoma INS1 cells, a model for the pancreatic β‐cell. This study …

Several studies have revealed that melatonin affects the insulin secretion via MT1 and MT2
receptor isoforms. Owing to the lack of selective MT1 receptor antagonists, we used RNA …

Melatonin influences insulin secretion both in vivo and in vitro.(i) The effects are MT1‐and
MT2‐receptor‐mediated.(ii) They are specific, high‐affinity, pertussis‐toxin‐sensitive, Gi …

Melatonin exerts some of its effects via G‐protein‐coupled membrane receptors. Two
membrane receptor isoforms, MT1 and MT2, have been described. The MT1 receptor is …

The pineal hormone melatonin influences insulin secretion, as well as glucagon and
somatostatin secretion, both in vivo and in vitro. These effects are mediated by two specific …