The use of surface‐based methods for the delivery of therapeutics has recently generated
increasing interest. These platforms have tremendous potential to minimize detrimental side …

Gene therapy is a medical technique intended for treatment of disorders caused by
defective, missing, or overexpressing genes. Efficient delivery vectors are necessary in order …

Gene therapy is a technique utilized to treat diseases caused by missing, defective or
overexpressing genes. Although viral vectors transfect cells efficiently, risks associated with …

Cationic lipid-and polymer-based nanodevices are considered appropriate alternatives for
virus-based particles for delivery of nucleic acids, including genes and siRNA, into …

The physicochemical properties and transfection efficacies of two samples of a cationic lipid
have been investigated and compared in 2D (monolayers at the air/liquid interface) and 3D …

Our study investigated the manufacturing of lipid-based nanotherapeutics with stealth
properties for siRNA delivery by employing a diffusion-driven microfluidic process in one or …

Currently self-assembled DNA delivery systems composed of DNA multivalent cations and
anionic lipids are considered to be promising tools for gene therapy. These systems become …

Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Ionizable lipids are a class of pharmaceutical excipients with a main application in lipid
nanoparticles for nucleic acid delivery. New ionizable lipids are needed to tune …

Publisher Summary Substantial improvements in gene transfection and expression by using
nonviral gene-delivery carriers have been witnessed in the last few years. Unfortunately …