The present study was designed to explore the possible protective effects of agmatine, a
known nitric oxide (NO) synthase inhibitor, against gentamicin-induced nephrotoxicity in …

Aim Gentamycin, a widely-used aminoglycoside antibiotic, is recognized as possessing
significant nephrotoxic potential in human beings. Gentamycin-induced nephrotoxicity is …

Kidney injury is a relatively common complication of the use of aminoglycosides.
Inflammation and oxidative stress play a key role in gentamicin (GM) nephrotoxicity. We …

In the present study, we investigated the antioxidative potencies of dihydropyridine calcium
antagonists prototype nifedipine, the second generation drug nitrendipine, and the long …

Acute kidney injury (AKI) is a serious disorder that accompanies rhabdomyolysis (RM). The
underlying mechanisms as well as protective approaches need to be investigated. This …

Background: There have been many studies in recent years concerning the role of nitric
oxide (NO) in acute renal failure (ARF). In this study, the effects of the inhibition or the …

The toxicity of aminoglycosides including gentamicin (GEN), the most widely used drug in
this category, is believed to be related to the generation of reactive oxygen species (ROS) in …

Aminoglycoside antibiotics have long been used in antibacterial therapy. Despite their
beneficial effects, aminoglycosides have considerable nephrotoxic and ototoxic side effects …

Gentamicin-induced nephrotoxicity has been well documented, although its underlying
mechanisms and preventive strategies remain to be investigated. The present study was …

GENTA nephrotoxicity is likely to be caused, among other factors, by an increase of
vasoconstrictors or a decrease of vasodilators such as NO. Few days after discontinuing …