Background Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease
marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys …

To date, CNS disease and neuropsychiatric symptoms of systemic lupus erythematosus (NP‐
SLE) have been understudied compared to end‐organ failure and peripheral pathology. In …

The brains of pathogen-free autoimmune MRL/lpr, NZBWF1 and NZB mice were examined
for central nervous system (CNS) inflammation in premoribund 8-week-old animals and at …

Many lupus patients develop neuropsychiatric manifestations, including cognitive
dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a …

Background Neuropsychiatric lupus (NPSLE) can be one of the earliest clinical
manifestations in human lupus. However, its mechanisms are not fully understood. In lupus …

Mouse models of autoimmunity, such as (NZB× NZW) F1, MRL/MpJ-Fas lpr (MRL-lpr) and
BXSB mice, spontaneously develop systemic lupus erythematosus (SLE)-like syndromes …

Animal models are extremely useful tools in defining pathogenesis and treatment of human
disease. For many years researchers believed that structural damage to the brain of …

Emotional disturbances are among the most common neuropsychiatric manifestations of
SLE, a systemic autoimmune disease with a strong female predominance. In this study, we …

Objective T cells are critical in the pathogenesis of systemic lupus erythematosus (SLE) in
that they secrete inflammatory cytokines, help autoantibody production, and form …

Manifestations of the human autoimmune disease systemic lupus erythematosus (SLE)
include a number of behavioral and cognitive deficits. The present study asks whether …