The blood–brain barrier (BBB), which imposes significant water permeability restriction,
effectively isolates the brain from the systemic circulation. Seemingly paradoxical, the …

Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of
water flux through the pericapillary (Virchow–Robin) space for both CSF production and …

The discovery of the water specific channel, aquaporin, and abundant expression of its
isoform, aquaporin-4 (AQP-4), on astrocyte endfeet brought about significant advancements …

Nanna MacAulay the fluorescent particles will not “follow the resulting osmotic gra dient into
the interstitium through intercellular clefts” 6 as water follows particles by osmosis, not the …

The unique properties of brain capillary endothelium, critical in maintaining the blood-brain
barrier (BBB) and restricting water permeability across the BBB, have important …

Fig. 1| Aquaporin 4 has direct and indirect roles in controlling fluid flow in the brain. Astrocyte
endfeet wrap around blood vessels at the blood–brain barrier, separated by a cerebrospinal …

Acentralpuzzleinourunderstandingofaquap… (AQP4) is the observation that paravascular
astrocytic end-feet express abundant AQP4, whereas the cerebral microvessels they abut …

The present study aimed to confirm the hypothesis that aquaporin-4 water channels (AQP4)
control solute transition into the brain parenchyma using image analysis of gadolinium …

The glymphatic system transports cerebrospinal fluid (CSF) into the brain via arterial
perivascular spaces and removes interstitial fluid from the brain along perivenous spaces …

Tissue-and cell-specific deletion of the Aqp4 gene is required to differentiate between the
numerous pools of aquaporin-4 (AQP4) water channels. A glial-conditional Aqp4 knockout …