The overlapping network of kinase-substrate interactions provides exquisite specificity in cell
signaling pathways, but also presents challenges to our ability to understand the …

Protein kinase Cα (PKCα) belongs to the family of AGC kinases that phosphorylate multiple
peptide substrates. Although the consensus sequence motif has been identified and used to …

We previously reported that some ATP competitive protein kinase C (PKC) inhibitors are
either competitive or uncompetitive inhibitors with respect to substrate peptides. In this …

Conformational changes acutely control protein kinase C (PKC). We have previously shown
that the autoinhibitory pseudosubstrate must be removed from the active site in order for 1) …

Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Intervention in protein kinase C (PKC) has a chequered history, partly because of the poor
selectivity of many inhibitors and partly a reflection of the sometimes antagonistic action of …

Protein kinase C (PKC) is a family of kinases that are critical in many cellular events. These
enzymes are activated by lipid-derived second messengers, are dependent on binding to …

Protein kinases play important regulatory roles in cells and organisms. Therefore, they are
subject to specific and tight mechanisms of regulation that ultimately converge on the …

Multidomain protein kinases, central controllers of signal transduction, use regulatory
domains to modulate catalytic activity in a complex cellular environment. Additionally, these …

PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …