Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein)
kinase are described that have activity in both cell-based assays of cytokine release and …

The p38 MAP kinase is thought to be involved in a variety of inflammatory and
immunological disorders such as rheumatoid arthritis. The pyridinylimidazole class of …

The p38 mitogen-activated protein kinase (MAPK) plays an important role in the production
of proinflammatory cytokines, making it an attractive target for the treatment of various …

Background: The p38 mitogen-activated protein (MAP) kinase regulates signal transduction
in response to environmental stress. Pyridinylimidazole compounds are specific inhibitors of …

Inhibition of the p38 map kinase pathway has been shown to be beneficial in the treatment
of inflammatory diseases. The first class of potent p38 kinase inhibitors was the …

Signal transduction through the p38 mitogen-activated protein (MAP) kinase pathway is
central to the transcriptional and translational control of cytokine and inflammatory mediator …

A novel series of highly potent and selective p38 MAP kinase inhibitors was developed
originating from a substituted N-aryl-6-pyrimidinone scaffold. SAR studies coupled with in …

Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein)
kinase are described which have activity in both cell-based assays of tumor necrosis factor-α …

The p38 mitogen-activated protein (MAP) kinases are a family of serine/threonine protein
kinases that play important roles in cellular responses to inflammation and external stress …

Inhibitors of the MAP kinase p38 provide a novel approach for the treatment of osteoporosis,
inflammatory disorders, and cancer. We have identified N-(3-tert-butyl-1-methyl-5-pyrazolyl) …