[HTML][HTML] A hybrid of amodiaquine and primaquine linked by gold (I) is a multistage antimalarial agent targeting heme detoxification and thiol redox homeostasis
CDS Pereira, HC Quadros, SY Aboagye… - …, 2022 - ncbi.nlm.nih.gov
Hybrid-based drugs linked through a transition metal constitute an emerging concept for
Plasmodium intervention. To advance the drug design concept and enhance the therapeutic …
Plasmodium intervention. To advance the drug design concept and enhance the therapeutic …
A hybrid of amodiaquine and primaquine linked by Gold (I) Is a multistage antimalarial agent targeting heme detoxification and thiol redox homeostasis
C De Souza Pereira, HC Quadros, SY Aboagye… - Pharmaceutics, 2022 - mdpi.com
Hybrid-based drugs linked through a transition metal constitute an emerging concept for
Plasmodium intervention. To advance the drug design concept and enhance the therapeutic …
Plasmodium intervention. To advance the drug design concept and enhance the therapeutic …
Antimalarial Agents Derived from Metal‐Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle
L Colina‐Vegas, M da Cruz B. Silva… - … A European Journal, 2023 - Wiley Online Library
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are
excellent ligands for metal coordination and are deployed as drugs for malaria treatment …
excellent ligands for metal coordination and are deployed as drugs for malaria treatment …
A Novel hybrid of chloroquine and primaquine linked by Gold (I): Multitarget and multiphase antiplasmodial agent
C de Souza Pereira, H Costa Quadros… - …, 2021 - Wiley Online Library
Plasmodium parasites kill 435 000 people around the world every year due to unavailable
vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical …
vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical …
[HTML][HTML] Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration
Amodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part
of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising …
of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising …
Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials
A variegate group of metallodrugs was evaluated in vitro for antimalarial activity through the
pLDH test. The panel comprised one mononuclear gold (III) complex,(Aubipy), three …
pLDH test. The panel comprised one mononuclear gold (III) complex,(Aubipy), three …
Medicinal chemistry updates on quinoline-and endoperoxide-based hybrids with potent antimalarial activity
The resistance of conventional antimalarial drugs against the malarial parasite continues to
pose a challenge to control the disease. The indiscriminate exploitation of the available …
pose a challenge to control the disease. The indiscriminate exploitation of the available …
Hybrid organometallic compounds as potent antimalarial agents
The resistance of the malaria parasite to the available drugs keeps on increasing and
gradually restricting the ability to manage this disease, ultimately leading to a massive …
gradually restricting the ability to manage this disease, ultimately leading to a massive …
Novel metalloantimalarials: Transmission blocking effects of water soluble Cu (I), Ag (I) and Au (I) phosphane complexes on the murine malaria parasite Plasmodium …
The water soluble phosphane complexes [M (L) 4] PF 6 (M= Cu (I), Ag (I)) and [Au (L) 4] Cl
(L= thp (tris (hydroxymethyl) phosphane) or PTA (1, 3, 5-triaza-7-phosphaadamantane)) …
(L= thp (tris (hydroxymethyl) phosphane) or PTA (1, 3, 5-triaza-7-phosphaadamantane)) …
An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite
GYS Delgado, M Navarro - Coordination Chemistry Reviews, 2024 - Elsevier
Malaria is one of the oldest and deadliest parasitic diseases globally, and it still poses a
global health issue today because of the emergence of new strains resistant to the first-line …
global health issue today because of the emergence of new strains resistant to the first-line …