[HTML][HTML] A hybrid of amodiaquine and primaquine linked by gold (I) is a multistage antimalarial agent targeting heme detoxification and thiol redox homeostasis

CDS Pereira, HC Quadros, SY Aboagye… - …, 2022 - ncbi.nlm.nih.gov
Hybrid-based drugs linked through a transition metal constitute an emerging concept for
Plasmodium intervention. To advance the drug design concept and enhance the therapeutic …

A hybrid of amodiaquine and primaquine linked by Gold (I) Is a multistage antimalarial agent targeting heme detoxification and thiol redox homeostasis

C De Souza Pereira, HC Quadros, SY Aboagye… - Pharmaceutics, 2022 - mdpi.com
Hybrid-based drugs linked through a transition metal constitute an emerging concept for
Plasmodium intervention. To advance the drug design concept and enhance the therapeutic …

Antimalarial Agents Derived from Metal‐Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle

L Colina‐Vegas, M da Cruz B. Silva… - … A European Journal, 2023 - Wiley Online Library
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are
excellent ligands for metal coordination and are deployed as drugs for malaria treatment …

A Novel hybrid of chloroquine and primaquine linked by Gold (I): Multitarget and multiphase antiplasmodial agent

C de Souza Pereira, H Costa Quadros… - …, 2021 - Wiley Online Library
Plasmodium parasites kill 435 000 people around the world every year due to unavailable
vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical …

[HTML][HTML] Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration

M Mbaba, TM Golding, RO Omondi, R Mohunlal… - European Journal of …, 2024 - Elsevier
Amodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part
of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising …

Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials

C Gabbiani, L Messori, MA Cinellu, A Casini… - Journal of inorganic …, 2009 - Elsevier
A variegate group of metallodrugs was evaluated in vitro for antimalarial activity through the
pLDH test. The panel comprised one mononuclear gold (III) complex,(Aubipy), three …

Medicinal chemistry updates on quinoline-and endoperoxide-based hybrids with potent antimalarial activity

A Uddin, M Chawla, I Irfan, S Mahajan… - RSC Medicinal …, 2021 - pubs.rsc.org
The resistance of conventional antimalarial drugs against the malarial parasite continues to
pose a challenge to control the disease. The indiscriminate exploitation of the available …

Hybrid organometallic compounds as potent antimalarial agents

P Singh, Y Preeti, B Parshad, D Yadav… - Recent Advances in …, 2024 - Elsevier
The resistance of the malaria parasite to the available drugs keeps on increasing and
gradually restricting the ability to manage this disease, ultimately leading to a massive …

Novel metalloantimalarials: Transmission blocking effects of water soluble Cu (I), Ag (I) and Au (I) phosphane complexes on the murine malaria parasite Plasmodium …

S Tapanelli, A Habluetzel, M Pellei, L Marchiò… - Journal of Inorganic …, 2017 - Elsevier
The water soluble phosphane complexes [M (L) 4] PF 6 (M= Cu (I), Ag (I)) and [Au (L) 4] Cl
(L= thp (tris (hydroxymethyl) phosphane) or PTA (1, 3, 5-triaza-7-phosphaadamantane)) …

An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite

GYS Delgado, M Navarro - Coordination Chemistry Reviews, 2024 - Elsevier
Malaria is one of the oldest and deadliest parasitic diseases globally, and it still poses a
global health issue today because of the emergence of new strains resistant to the first-line …