Sepsis still represents an important clinical and economic challenge for intensive care units.
Severe complications like multi-organ failure with high mortality and the lack of specific …

Background The sepsis syndromes, frequently complicated by pulmonary and cardiac
dysfunction, remain a major cause of death amongst the critically ill. Targeted therapies …

BACKGROUND The receptor for advanced glycation end products (RAGE) is a pattern-
recognition receptor involved in the pathogenesis of inflammatory diseases. However, the …

While the initiation of the adaptive and innate immune response is well understood, less is
known about cellular mechanisms propagating inflammation. The receptor for advanced …

Accumulating evidence shows that RAGE has an important function in the pathogenesis of
sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase …

Septic shock is a severe systemic response to bacterial infection. Receptor for advanced
glycation end products (RAGE) plays a role in immune reactions to recognize specific …

Acute lung injury (ALI) is an inflammatory lung disease caused by sepsis, infection, or
ischemia-reperfusion. The receptor for advanced glycation end-products (RAGE) signaling …

ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …

The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor
capable of recognizing multiple pathogen-associated and danger-associated molecular …

The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor
and evolutionary member of the immunoglobulin superfamily that is involved in the host …