Receptor for advanced glycation end products (RAGE) in vascular and inflammatory diseases

N Mahajan, V Dhawan - International journal of cardiology, 2013 - Elsevier
Historically, the receptor for advanced glycation end products (RAGE) was thought to
exclusively play an important role under hyperglycemic conditions. However, more and …

Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury

LG Bucciarelli, M Kaneko, R Ananthakrishnan… - Circulation, 2006 - Am Heart Assoc
Background—The beneficial effects of reperfusion therapies have been limited by the
amount of ischemic damage that occurs before reperfusion. To enable development of …

Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response

AM Schmidt, R Clynes, B Moser, SF Yan… - Current molecular …, 2007 - ingentaconnect.com
The family of RAGE ligands, including Advanced Glycation Endproducts (AGEs),
S100/calgranulins, High Mobility Group Box-1 (HMGB1) and amyloid β peptide (Aβ) and β …

Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors

H Singh, DK Agrawal - Drug development research, 2022 - Wiley Online Library
Receptor for advanced glycation end products (RAGE) is a 45 kDa transmembrane receptor
of immunoglobulin family that can bind to various endogenous and exogenous ligands and …

[HTML][HTML] Receptor for advanced glycation end-products promotes activation of alveolar macrophages through the NLRP3 Inflammasome/TXNIP axis in acute lung …

W Lenga Ma Bonda, M Fournet, R Zhai, J Lutz… - International Journal of …, 2022 - mdpi.com
The roles of thioredoxin-interacting protein (TXNIP) and receptor for advanced glycation end-
products (RAGE)-dependent mechanisms of NOD-like receptor family, pyrin domain …

Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges

Y Hattori, K Hattori, T Suzuki, N Matsuda - Pharmacology & therapeutics, 2017 - Elsevier
Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

[HTML][HTML] Clinical and biological markers for predicting ARDS and outcome in septic patients

J Villar, R Herrán-Monge, E González-Higueras… - Scientific Reports, 2021 - nature.com
Sepsis is a common cause of acute respiratory distress syndrome (ARDS) associated with a
high mortality. A panel of biomarkers (BMs) to identify septic patients at risk for developing …

RAGE and its ligands: from pathogenesis to therapeutics

N Jangde, R Ray, V Rai - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

Emerging therapeutic targets for sepsis

EW Tindal, BE Armstead, SF Monaghan… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury

CS Calfee, LB Ware, MD Eisner, PE Parsons… - Thorax, 2008 - thorax.bmj.com
Objectives: To determine whether baseline plasma levels of the receptor for advanced
glycation end products (RAGE), a novel marker of alveolar type I cell injury, are associated …