Lymphocyte subpopulations in Sjögren's syndrome are distinct in anti-SSA-positive patients and related to disease activity

F Barcelos, C Martins, N Madeira, M Ângelo-Dias… - Clinical …, 2021 - Springer
Objectives Sjögren's syndrome (SjS) patients exhibit great phenotypical heterogeneity,
reinforced by the positiveness of anti-SSA antibody. We aimed to evaluate lymphocyte …

[PDF][PDF] Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome

JC Lin, KL Pan, CF Li, KF Lee, KY Lin, KM Lin, CY Lin - Heliyon, 2023 - cell.com
Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to
now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial …

Rituximab modulates IL-17 expression in the salivary glands of patients with primary Sjögren's syndrome

F Ciccia, G Guggino, A Rizzo, R Alessandro… - …, 2014 - academic.oup.com
Objective. The aim of this study was to evaluate the role of rituximab (RTX) in modulating the
expression of the IL-17/IL-23 pathway in the salivary glands (SGs) of patients with primary …

Is the T follicular regulatory: follicular helper T cell ratio in blood a biomarker for ectopic lymphoid structure formation in sjögren's syndrome? comment on the article by …

GM Verstappen, U Nakshbandi, E Mossel… - Arthritis & …, 2018 - Wiley Online Library
We read with great interest the recent article by Fonseca et al in which they elegantly
showed that T follicular regulatory (Tfr) cells were enriched in blood as well as in matched …

High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome

E Desvaux, P Hemon, P Soret, C Le Dantec… - Journal of …, 2023 - Elsevier
Objective While the involvement of IL-7/IL-7R axis in pSS has been described in relation to T
cells, little is known about the contribution of this pathway in relationship with other immune …

[HTML][HTML] Impact of corticosteroids on the proportions of circulating Tfh cell subsets in patients with systemic lupus erythematous

M Mao, S Xu, L Lin, D Dong, M Xue, S He… - Frontiers in Medicine, 2022 - frontiersin.org
Objectives: The aim of this study was to analyze the distribution of Tfh in lupus patients, and
the effects of steroid on circulating Tfh cells of patients. Methods: Circulating Tfh cell subsets …

[HTML][HTML] Exploiting the role of T cells in the pathogenesis of Sjögren's syndrome for therapeutic treatment

Q An, J Zhao, X Zhu, B Yang, Z Wu, Y Su… - Frontiers in …, 2022 - frontiersin.org
Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and
lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects …

Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren's syndrome

J Sun, H Zhang, S Liu, C Lian, Z Chen… - Annals of the …, 2020 - ard.bmj.com
Background Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease
characterised by aberrant B cell hyperactivation, whose mechanism is partially understood …

Increased circulating follicular Treg cells are associated with lower levels of autoantibodies in patients with rheumatoid arthritis in stable remission

C Liu, D Wang, S Lu, Q Xu, L Zhao, J Zhao… - Arthritis & …, 2018 - Wiley Online Library
Objective To examine the expression and changes in function of circulating CD 4+ CXCR 5+
FoxP3+ follicular Treg (Tfr) cells in patients with active rheumatoid arthritis (RA) and in …

Alteration of innate lymphoid cell homeostasis mainly concerns salivary glands in primary Sjögren's syndrome

L Kawka, R Felten, C Schleiss, JD Fauny… - RMD open, 2023 - rmdopen.bmj.com
Objective Innate lymphoid cells (ILCs) are a cell population implicated in the pathogenesis
of various chronic inflammatory diseases, but little is known about their role in primary …