Glycans in drug discovery

P Valverde, A Ardá, NC Reichardt… - …, 2019 - pubs.rsc.org
Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …

Emerging glyco‐based strategies to steer immune responses

M Anderluh, F Berti, A Bzducha‐Wróbel… - The FEBS …, 2021 - Wiley Online Library
Glycan structures are common posttranslational modifications of proteins, which serve
multiple important structural roles (for instance in protein folding), but also are crucial …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Design and synthesis of glycomimetics: Recent advances

A Tamburrini, C Colombo… - Medicinal research …, 2020 - Wiley Online Library
In the past few decades, our understanding of glycan information‐encoding power has
notably increased, thus leading to a significant growth also in the design and synthesis of …

[PDF][PDF] Effects of neighboring glycans on antibody–carbohydrate interaction

CH Liang, SK Wang, CW Lin, CC Wang… - Angewandte Chemie …, 2011 - academia.edu
Carbohydrate recognition is a crucial event in many biological processes, including the
progression of diseases such as AIDS, influenza, and cancer.[1–4] Thus, characterization …

Glycotherapy: new advances inspire a reemergence of glycans in medicine

JE Hudak, CR Bertozzi - Chemistry & biology, 2014 - cell.com
The beginning of the 20 th century marked the dawn of modern medicine with glycan-based
therapies at the forefront. However, glycans quickly became overshadowed as DNA-and …

Lectins: getting familiar with translators of the sugar code

S André, H Kaltner, JC Manning, PV Murphy… - Molecules, 2015 - mdpi.com
The view on the significance of the presence of glycans in glycoconjugates is undergoing a
paradigmatic change. Initially mostly considered to be rather inert and passive, the concept …

Exploring and exploiting the therapeutic potential of glycoconjugates

KJ Doores, DP Gamblin… - Chemistry–A European …, 2006 - Wiley Online Library
Carbohydrates, either bound to proteins or in lipids, play essential roles as communication
molecules in many intercellular and intracellular processes. In particular, carbohydrates are …

Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …