Deep tissue imaging has become state of the art in biology, but now the problem is to
quantify spatial information in a global, organ‐wide context. Although access to the raw data …

Background To date, pathological examination of specimens remains largely qualitative.
Quantitative measures of tissue spatial features are generally not captured. To gain …

Secondary lymphoid organs have developed segregated niches that are able to initiate and
maintain effective immune responses. Such global organization requires tight control of …

A central question in immunology is what features allow the immune system to respond in a
timely manner to a variety of pathogens encountered at unanticipated times and diverse …

In this study, we discuss critical issues in modelling the structure and function of lymph
nodes (LNs), with emphasis on how LN physiology is related to its multi-scale structural …

Background The efficiency of lymph nodes depends on tissue structure and organization,
which allow the coordination of lymphocyte traffic. Despite their essential role, our …

Dendritic cells (DCs) capture pathogens and foreign antigen (Ag) in peripheral tissues and
migrate to secondary lymphoid tissues, such as lymph nodes (LNs), where they present …

The function of mammalian cells is largely influenced by their tissue microenvironment.
Advances in spatial transcriptomics open the way for studying these important determinants …

Observational studies of human tissues have contributed to the literature for many years.
However, recent initiatives driving human sample collection for research, the acquisition of …

Our aim is to complement observer-dependent approaches of immune cell evaluation in
microscopy images with reproducible measures for spatial composition of lymphocytic …