Stem cell therapy for the spinal cord

EM Donnelly, J Lamanna, NM Boulis - Stem Cell Research & Therapy, 2012 - Springer
Injury and disease of the spinal cord are generally met with a poor prognosis. This poor
prognosis is due not only to the characteristics of the diseases but also to our poor ability to …

Magnetic Resonance Tracking of Magnetically Labeled Autologous Bone Marrow CD34+ Cells Transplanted into the Spinal Cord via Lumbar Puncture Technique in Patients …

F Callera, CMTP de Melo - Stem cells and development, 2007 - liebertpub.com
The purpose of this study was to demonstrate the possibility of delivering autologous bone
marrow precursor cells into the spinal cord via lumbar puncture technique (LP) in patients …

Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation

M Chopp, XH Zhang, Y Li, L Wang, J Chen, D Lu… - …, 2000 - journals.lww.com
We tested the hypothesis that transplantation of bone marrow stromal cells (MSCs) into the
spinal cord after a contusion injury promotes functional outcome. Rats (n= 31) were …

Effects of intrathecal injection of the conditioned medium from bone marrow stromal cells on spinal cord injury in rats

K Kanekiyo, T Wakabayashi, N Nakano… - Journal of …, 2018 - liebertpub.com
Bone marrow stromal cells (BMSCs) have been studied for the treatment of spinal cord injury
(SCI). In previous studies, we showed that the transplantation of BMSCs, even though they …

Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue

K Satake, J Lou, LG Lenke - Spine, 2004 - journals.lww.com
Study Design. Experimental spinal cord injury using a rat model. Objective. To investigate
the potential for survival and migration of transplanted mesenchymal stem cells through the …

Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures

T Hamasaki, N Tanaka, N Kamei, O Ishida, S Yanada… - Spine, 2007 - journals.lww.com
Study Design. An in vitro, rat animal study was conducted. Objective. To assess the
corticospinal axon growth potential in varying concentrations of neural progenitor cells …

New method for transplantation of neurosphere cells into injured spinal cord through cerebrospinal fluid in rat

S Wu, Y Suzuki, M Kitada, K Kataoka, M Kitaura… - Neuroscience …, 2002 - Elsevier
Here we report a novel method of supplying cultured neurosphere cells to the injured spinal
cord, by injection of cells into the cerebrospinal fluid (CSF) through the fourth ventricle or …

A surgical technique of spinal cord cell transplantation in amyotrophic lateral sclerosis

M Blanquer, MA Pérez-Espejo… - Journal of neuroscience …, 2010 - Elsevier
We report an original method for implanting bone marrow stem cells within the spinal cord
parenchyma. This method was used for the experimental treatment of patients diagnosed …

In Vivo Fluorescence Tracking of Bone Marrow Stromal Cells Transplanted into a Pneumatic Injury Model of Rat Spinal Cord

S Yano, S Kuroda, JB Lee, H Shichinohe… - Journal of …, 2005 - liebertpub.com
Recent experimental studies have shown that bone marrow stromal cells (BMSC)
differentiate into neural cells and reduce neurological deficits when transplanted into …

Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration?

J Vaquero, M Zurita, S Oya, M Santos - Neuroscience letters, 2006 - Elsevier
Recent studies showed the therapeutic effect of bone marrow stromal cells (BMSC) after
spinal cord injury (SCI). In the present study, we compared the effect of systemic and local …