Therapeutic benefit of intrathecal injection of marrow stromal cells on ischemia-injured spinal cord

E Shi, T Kazui, X Jiang, N Washiyama… - The Annals of thoracic …, 2007 - Elsevier
BACKGROUND: Prophylactic transplantation of marrow stromal cells (MSCs) before spinal
cord ischemia has been shown to attenuate neurologic injures. We sought to investigate the …

Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats

DP Ankeny, DM McTigue, LB Jakeman - Experimental neurology, 2004 - Elsevier
Contusive spinal cord injury (SCI) produces large fluid-, debris-and inflammatory cell-filled
cystic cavities that lack structure to support significant axonal regeneration. The recent …

Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells

A Mahmood, D Lu, L Wang, Y Li, M Lu, M Chopp - Neurosurgery, 2001 - journals.lww.com
OBJECTIVE: To study the effect of bone marrow stromal cells administered intravenously to
female rats subjected to traumatic brain injury. METHODS: We injected marrow stromal cells …

A phase III clinical trial showing limited efficacy of autologous mesenchymal stem cell therapy for spinal cord injury

SK Oh, KH Choi, JY Yoo, DY Kim, SJ Kim… - Neurosurgery, 2016 - journals.lww.com
BACKGROUND: In our previous report, 3 of 10 patients with spinal cord injury who were
injected with autologous mesenchymal stem cells (MSCs) showed motor improvement in the …

[HTML][HTML] The cell culture expansion of bone marrow stromal cells from humans with spinal cord injury: implications for future cell transplantation therapy

KT Wright, W El Masri, A Osman, S Roberts, J Trivedi… - Spinal Cord, 2008 - nature.com
Study design: Previous studies have shown that transplantation of bone marrow stromal
cells (MSCs) in animal models of spinal cord injury (SCI) encourages functional recovery …

Repetitive intrathecal catheter delivery of bone marrow mesenchymal stromal cells improves functional recovery in a rat model of contusive spinal cord injury

D Cizkova, I Novotna, L Slovinska, I Vanicky… - Journal of …, 2011 - liebertpub.com
Transplantation of bone marrow mesenchymal stromal cells (MSCs) has been shown to
improve the functional recovery in various models of spinal cord injury (SCI). However, the …

Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs

D Usvald, P Vodicka, J Hlucilova… - Cell …, 2010 - journals.sagepub.com
In recent studies using a rat aortic balloon occlusion model, we have demonstrated that
spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads …

An attempt to treat patients who have injured spinal cords with intralesional implantation of concentrated autologous bone marrow cells

A Attar, M Ayten, M Ozdemir, E Ozgencil, M Bozkurt… - …, 2011 - Taylor & Francis
Background aims. Spinal cord injury is common among young subjects involved in motor
vehicle accidents. Mechanisms and attempts to reverse post-traumatic pathophysiologic …

Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture

Y Suzuki, N Ishikawa, K Omae, T Hirai… - Restorative …, 2014 - content.iospress.com
Purpose: This study was conducted to assess the safety and feasibility of intrathecal
transplantation of autologous bone marrow-derived mononuclear cells for the treatment of …

Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord

M Inoue, O Honmou, S Oka, K Houkin, K Hashi… - Glia, 2003 - Wiley Online Library
The remyelinating potential of autologous bone marrow cells was studied after direct
injection and following intravenous injection into rats with a demyelinated lesion in the …