Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine

A Podda, EC De Luca, B Contu, R Furlan, A Maida… - The Journal of …, 1994 - Elsevier
The safety and immunogenicity of an acellular pertussis vaccine containing the genetically
detoxified pertussis toxin PT-9K/129C, filamentous hemagglutinin, and pertactin, together …

Comparison of a three-component acellular pertussis vaccine with whole cell pertussis vaccine in two-month-old children

ME PICHICHERO, JL GREEN… - The Pediatric …, 1994 - journals.lww.com
An acellular pertussis vaccine (DTaP) containing pertussis toxoid, filamentous
hemagglutinin and the 69-kDa outer membrane protein (pertactin) was compared with …

Acellular pertussis vaccine: immunogenicity and safety of an acellular pertussisvs. a whole cell pertussis vaccine combined with diphtheria and tetanus toxoids as a …

ME Pichichero, TJ BADGETT… - The Pediatric …, 1987 - journals.lww.com
An acellular pertussis vaccine principally containing two purified pertussis antigens,
filamentous hemagglutinin and lymphocytosis-promoting factor, combined with diphtheria …

Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous …

M KIMURA, H KUNO‐SAKAI, H KAMIYA… - Pediatrics …, 1995 - Wiley Online Library
This is the report on a prospective, single blind, comparative study of a component acellular
pertussis vaccine produced by a combination of detoxified, column purified pertussis toxin …

Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight …

HJ Schmitt, K Beutel, A Schuind, M Knuf… - The Journal of …, 1997 - Elsevier
Objectives: The primary objective was to assess the nature and incidence of adverse events
after a fourth dose of a tricomponent acellular pertussis-diphtheria-tetanus vaccine given in …

Acellular pertussis vaccine composed of genetically inactivated pertussis toxin: safety and immunogenicity in 12-to 24-and 2-to 4-month-old children

A Podda, EC De Luca, L Titone, AM Casadei… - The Journal of …, 1992 - Elsevier
To determine whether a nontoxic derivative of pertussis toxin obiained by recombinant DNA
technology, PT-9K/129G, is a good candidate for a new pertussis vaccine, we examined the …

Primum non nocere: a pharmacologically inert pertussis toxoid alone should be the next pertussis vaccine

JB ROBBINS, M PITTMAN, B TROLLFORS… - The Pediatric …, 1993 - journals.lww.com
This review was stimulated in part by three articles that presented a view of acellular
pertussis vaccine development," which we believe is not supported by the clinical and …

Responses to primary and a booster dose of acellular, component, and whole-cell pertussis vaccines initiated at 2 months of age

LM Huang, CY Lee, TY Lin, JM Chen, PI Lee, CY Hsu - Vaccine, 1996 - Elsevier
A second generation acellular pertussis vaccine (component pertussis vaccine) containing
purified pertussis toxin (PT) and filamentous hemagglutinin (FHA) was tested for its …

Comparative efficacy of acellular pertussis vaccines: an analysis of recent trials

JD Cherry - The Pediatric infectious disease journal, 1997 - journals.lww.com
Diphtheria-tetanus-acellular pertussis vaccines have been licensed in the United States
since 1991. Compared with the whole cell pertussis component diphtheria-tetanus-pertussis …

Comparison of a three-component acellular pertussis vaccine with a whole-cell pertussis vaccine in 15-through 20-month-old infants

HH Bernstein, EP Rothstein… - …, 1994 - publications.aap.org
Objective. To compare the immunogenicity and reactogenicity of a diphtheria and tetanus
toxoids and three-component acellular pertussis vaccine (DTaP) with a diphtheria and …