Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies
Inhibition of high cholinesterase levels including acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
Cholinesterase inhibition activity and docking simulation study of coumarin mannich base derivatives
Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two
major forms of cholinesterases (ChEs) is considered as the common approach for the …
major forms of cholinesterases (ChEs) is considered as the common approach for the …
[PDF][PDF] In silico study of phytochemicals for anticholinesterase activity as a potential drug target against Alzheimer's disease
TT Khandagale, K Singh, S Sinha, A Puri - Chem. Biol. Lett, 2022 - researchgate.net
CONCLUSION Among the tested 12 phytochemicals in this in silico study, two
phytochemicals Quercetin and Genkwanin have shown efficient binding affinity with active …
phytochemicals Quercetin and Genkwanin have shown efficient binding affinity with active …
Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives
Coumarins of synthetic or natural origins are an important chemical class exerting diverse
pharmacological activities. In the present study, 26 novel O-alkylcoumarin derivatives were …
pharmacological activities. In the present study, 26 novel O-alkylcoumarin derivatives were …
Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of …
A Kuppusamy, M Arumugam, S George - International journal of biological …, 2017 - Elsevier
The current objective of the study is to identify inhibitory affinity potential of the certain
commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) …
commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) …
Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids
The major enzyme responsible for the hydrolytic breakdown of the neurotransmitter
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles
In a continuation of our previous work for the exploration of novel enzyme inhibitors, two new
coumarin-thiazole 6 (a–o) and coumarin-oxadiazole 11 (a–h) hybrids have been designed …
coumarin-thiazole 6 (a–o) and coumarin-oxadiazole 11 (a–h) hybrids have been designed …
In silico discovery of noteworthy multi-targeted acetylcholinesterase inhibitors for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial and fatal neurodegenerative disorder. Memory
loss and cognitive decline occur due to death of brain cells. Various important hallmarks of …
loss and cognitive decline occur due to death of brain cells. Various important hallmarks of …
Multi-combined QSAR, molecular docking, molecular dynamics simulation, and ADMET of Flavonoid derivatives as potent cholinesterase inhibitors
H Soufi, M Moussaoui, S Baammi… - Journal of …, 2023 - Taylor & Francis
In searching for a new and efficient therapeutic agent against Alzheimer's disease, a
Quantitative structure-activity relationship (QSAR) was derived for 45 Flavonoid derivatives …
Quantitative structure-activity relationship (QSAR) was derived for 45 Flavonoid derivatives …
Quinoline containing chalcone derivatives as cholinesterase inhibitors and their in silico modeling studies
MS Shah, M Najam-ul-Haq, HS Shah, SUF Rizvi… - … Biology and Chemistry, 2018 - Elsevier
Cholinesterases (ChEs) play a vital role in regulating cholinergic transmission. Inhibition of
ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative …
ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative …