Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds

JJ Mendez, M Ghaedi, D Steinbacher… - … Engineering Part A, 2014 - liebertpub.com
Identification of appropriate donor cell types is important for lung cell therapy and for lung
regeneration. Previous studies have indicated that mesenchymal stromal cells derived from …

Initial binding and recellularization of decellularized mouse lung scaffolds with bone marrow-derived mesenchymal stromal cells

AB Daly, JM Wallis, ZD Borg, RW Bonvillain… - … Engineering Part A, 2012 - liebertpub.com
Recellularization of whole decellularized lung scaffolds provides a novel approach for
generating functional lung tissue ex vivo for subsequent clinical transplantation. To explore …

Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema

DMLW Kruk, M Wisman, HG Bruin… - … of Physiology-Lung …, 2021 - journals.physiology.org
Mesenchymal stromal cells (MSCs) may provide crucial support in the regeneration of
destructed alveolar tissue (emphysema) in chronic obstructive pulmonary disease (COPD) …

Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans

KA Sinclair, ST Yerkovich, T Chen, JL McQualter… - Stem Cells, 2016 - academic.oup.com
Stromal support is critical for lung homeostasis and the maintenance of an effective
epithelial barrier. Despite this, previous studies have found a positive association between …

Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung

AM Hoffman, JA Paxson, MR Mazan… - Stem cells and …, 2011 - liebertpub.com
While multipotent mesenchymal stromal cells have been recently isolated from adult lung (L-
MSCs), there is very limited data on their biological properties and therapeutic potential in …

Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells

S Rolandsson, AA Sjöland, JC Brune… - BMJ open …, 2014 - bmjopenrespres.bmj.com
Background Mesenchymal stem cells (MSC) have not only been implicated in the
development of lung diseases, but they have also been proposed as a future cell-based …

Lung-resident mesenchymal stromal cells are tissue-specific regulators of lung homeostasis

SN Sveiven, TM Nordgren - American Journal of …, 2020 - journals.physiology.org
Until recently, data supporting the tissue-resident status of mesenchymal stromal cells
(MSC) has been ambiguous since their discovery in the 1950–60s. These progenitor cells …

Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties

M Khatri, TD O'Brien, KS Chattha, LJ Saif - Stem Cell Research & Therapy, 2015 - Springer
Introduction Mesenchymal stem (stromal) cells (MSCs) possess self-renewal, differentiation
and immunoregulatory properties, and therefore are being evaluated as cellular therapy for …

Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung

KA Sinclair, ST Yerkovich, PMA Hopkins… - Stem cell research & …, 2016 - Springer
Background Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are capable of
repairing wounded lung epithelial cells by donating cytoplasmic material and mitochondria …

Hypertensive rat lungs retain hallmarks of vascular disease upon decellularization but support the growth of mesenchymal stem cells

ME Scarritt, RW Bonvillain, BJ Burkett… - … Engineering Part A, 2014 - liebertpub.com
There are an insufficient number of donor organs available to meet the demand for lung
transplantation. This issue could be addressed by regenerating functional tissue from …