Time-of-flight secondary ion mass spectrometry (ToF-SIMS) equipped with a gold ion gun
was used to image mouse embryo sections and differentiate tissue types (brain, spinal cord …

Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical
technique rapidly expanding in use in biological studies. This technique is based on high …

Currently two techniques exist for 3D reconstruction of biological samples by time-of-flight
secondary ion mass spectrometry (ToF-SIMS). The first, based on microtomy and combining …

We use time-of-flight secondary ion mass spectrometry (TOF-SIMS) to image and classify
individual cells on the basis of their characteristic mass spectra. Using statistical data …

Studies of the chemical composition of organs using mass spectrometry imaging become an
important issue to better understand the mechanisms involved in various diseases …

Imaging by secondary ion mass spectrometry coupled to time-of-flight mass analysis (TOF-
SIMS) is a method of which the applications have greatly increased since 10 years. Taking …

Secondary ion mass spectrometry is a powerful method for imaging biological samples with
high spatial resolution. Whole section time-of-flight-secondary ion mass spectrometry (TOF …

The ability to image cells and tissues with chemical and molecular specificity could greatly
expand our understanding of biological processes. The subcellular resolution mass spectral …

C. elegans is a biomedical key model organism as it is a simple, easy to maintain eukaryote,
which shares many gene homologues with higher mammals. As each of its cells has been …

A 20keV C60+ ion source was mounted onto a commercial MALDI/electrospray orthogonal
ToF mass spectrometer. Cross-sectional mouse brain and lung slices between 5 and 10μm …