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[HTML][HTML] Therapeutic potential of the sphingosine kinase 1 inhibitor, PF-543

X Yi, X Tang, T Li, L Chen, H He, X Wu, C Xiang… - Biomedicine & …, 2023 - Elsevier
PF-543 is a sphingosine kinase 1 (SPHK1) inhibitor developed by Pfizer and is currently
considered the most potent selective SPHK1 inhibitor. SPHK1 catalyses the production of …
被引用次数：4 相关文章 所有 3 个版本

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors …

D Plano, S Amin, AK Sharma - Journal of medicinal chemistry, 2014 - ACS Publications
Sphingosine kinase (SphK) is an oncogenic lipid kinase that regulates the sphingolipid
metabolic pathway that has been shown to play a role in numerous hyperproliferative …
被引用次数：101 相关文章 所有 4 个版本
[HTML] spandidos-publications.com

[HTML][HTML] Sphingosine kinase inhibitors: A patent review

M Cao, C Ji, Y Zhou, W Huang… - International …, 2018 - spandidos-publications.com
Sphingosine kinases (SphKs) catalyze the conversion of the sphingosine to the
promitogenic/migratory product, sphingosine-1-phosphate (S1P). SphK/S1P pathway has …
被引用次数：34 相关文章 所有 7 个版本

Sphingosine kinases signalling in carcinogenesis

G Marfe, G Mirone, A Shukla… - Mini reviews in …, 2015 - ingentaconnect.com
Sphingosine kinases (Sphk1 and 2) regulate the prodution of sphingosine-1-phosphate
(S1P), that is key molecule in cancer development. SphK1, which is commonly …
被引用次数：33 相关文章 所有 4 个版本
[HTML] mdpi.com

[HTML][HTML] Design and development of novel urea, sulfonyltriurea, and sulfonamide derivatives as potential inhibitors of sphingosine kinase 1

S Roy, AD Mahapatra, T Mohammad, P Gupta… - Pharmaceuticals, 2020 - mdpi.com
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and
inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been …
被引用次数：13 相关文章 所有 10 个版本
[HTML] nih.gov

Sphingosine kinase inhibitors: a review of patent literature (2006-2015)

KR Lynch, SB Thorpe, WL Santos - Expert opinion on therapeutic …, 2016 - Taylor & Francis
ABSTRACT Introduction: Sphingosine kinase (SphK1 & SphK2) is the sole source of the
pleiotropic lipid mediator, sphingosine-1-phosphate (S1P). S1P has been implicated in a …
被引用次数：30 相关文章 所有 5 个版本

The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy

X Zheng, W Li, L Ren, J Liu, X Pang, X Chen… - Pharmacology & …, 2019 - Elsevier
Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate
(S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell …
被引用次数：85 相关文章 所有 4 个版本
[HTML] nih.gov

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

S Pyne, R Bittman, NJ Pyne - Cancer research, 2011 - AACR
There is considerable evidence that sphingosine kinases play a key role in cancer
progression, which might involve positive selection of cancer cells that have been provided …
被引用次数：119 相关文章 所有 11 个版本
[HTML] nih.gov

Transforming sphingosine kinase 1 inhibitors into dual and sphingosine kinase 2 selective inhibitors: design, synthesis, and in vivo activity

ES Childress, Y Kharel, AM Brown… - Journal of medicinal …, 2017 - ACS Publications
Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with its five
G-protein coupled receptors (S1P1–5) to regulate cell growth and survival and has been …
被引用次数：43 相关文章 所有 5 个版本

Discovery of a potent and selective sphingosine kinase 1 inhibitor through the molecular combination of chemotype-distinct screening hits

ME Schnute, MD McReynolds, J Carroll… - Journal of Medicinal …, 2017 - ACS Publications
Sphingosine kinase (SphK) is the major source of the lipid mediator and G protein-coupled
receptor agonist sphingosine-1-phosphate (S1P). S1P promotes cell growth, survival, and …
被引用次数：44 相关文章 所有 5 个版本