Interferon alpha for treatment of chronic myeloid leukemia

B Simonsson, H Hjorth-Hansen… - Current drug …, 2011 - ingentaconnect.com
Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced
in the early 1980s. Several clinical trials showed a survival advantage for patients treated …

Practical guidelines for the management of chronic myelogenous leukemia with interferon alpha

S O'Brien, H Kantarjian, M Talpaz - Leukemia & lymphoma, 1996 - Taylor & Francis
Interferon-A (IFN-A) is an effective agent in the treatment of chronic myelogenous leukemia
(CML). Hematologic remissions occur in the majority of patients with newly diagnosed …

Long-Term Follow-Up of the Italian Trial of Interferon- Versus Conventional Chemotherapy in Chronic Myeloid Leukemia

Italian Cooperative Study Group on … - Blood, The Journal …, 1998 - ashpublications.org
Several prospective randomized studies have shown that the treatment of chronic myeloid
leukemia with interferon-(IFN-) prolongs the survival by comparison with conventional …

Combination therapy with interferon alpha‐2b plus low‐dose interferon gamma in pretreated patients with Ph‐positive chronic myelogenous leukaemia

UB Wandl, O Kloke, M Nagel‐Hiemke… - British journal of …, 1992 - Wiley Online Library
Between March 1988 and July 1990, 28 adults with chronic myelogenous leukaemia (CML)
were treated with a combination of recombinant human interferon (IFN) alpha‐2b sc (initial …

Low doses of interferon-α are as effective as higher doses in inducing remissions and prolonging survival in chronic myeloid leukemia

JR Schofield, WA Robinson, JR Murphy… - Annals of internal …, 1994 - acpjournals.org
Objective: To determine the toxicity and efficacy of low-dose interferon-α therapy in inducing
remissions and prolonging survival in patients with chronic myeloid leukemia. Design …

Cytogenetic remissions in chronic myelogenous leukemia using interferon alpha-2a and hydroxyurea with or without low-dose cytosine arabinoside

F Guilhot, B Dreyfus, A Brizard, JL Huret… - Leukemia & …, 1991 - Taylor & Francis
Twenty-four patients with Philadelphia positive (Ph+) chronic myelogenous leukemia
including 12 who were previously untreated, received recombinant interferon alpha-2a …

Interferon-alfa for chronic myeloid leukemia

M Baccarani, D Russo, G Rosti, G Martinelli - Seminars in hematology, 2003 - Elsevier
Interferon-alfa (IFNα) became the first-line agent for the treatment of chronic myeloid
leukemia (CML) because it prolongs survival significantly compared to conventional …

A randomized trial comparing interferon-alpha with busulfan for newly diagnosed chronic myelogenous leukemia in chronic phase

K Ohnishi, R Ohno, M Tomonaga, N Kamada… - 1995 - ashpublications.org
A multicenter randomized study was conducted to compare the effect of interferon-alpha
(IFN-alpha) with that of busulfan in newly diagnosed patients with chronic myelogenous …

Monitoring treatment and survival in chronic myeloid leukemia.

AM Liberati… - Journal of Clinical …, 1999 - research.unipg.it
Purpose: 79 monitor treatment results and survival in chronic myeloid leukemia after
allogeneic bone marrow transplantation (alloBMT) and the introduction of interferon alpha …

Chronic myelogenous leukaemia: haematological remissions with alpha interferon

M Talpaz, K McCredie, HK Jian, J Trujillo… - British journal of …, 1986 - Wiley Online Library
Twenty‐seven consecutive patients with previously untreated, or minimally treated benign
phase Philadelphia‐chromosome‐positive, chronic myelogenous leukaemia (CML) were …