All types of progressive chronic kidney disease (CKD) inevitably induce renal fibrosis, the
hallmark of which is the activation and accumulation of a large number of matrix-producing …

Fibroblasts are key mediators of fibrosis in the kidney and other organs, but their origin
during fibrosis is still not completely clear. Activated fibroblasts likely arise from resident …

Mature tubular epithelial cells in adult kidney can undergo epithelial-to-mesenchymal
transition (EMT), a phenotypic conversion that is fundamentally linked to the pathogenesis of …

Abstract Epithelial-mesenchymal transition (EMT), a process by which differentiated
epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing …

PURPOSE: Tubulointerstitial fibrosis is the final common pathway to end stage renal
disease. The pathophysiology of renal fibrosis involves fibroblast proliferation, macrophage …

Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by
which injured renal tubular cells transform into mesenchymal cells that contribute to the …

Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …

[Frontiers in Bioscience 13, 6991-6998, May 1, 2008] 6991 Fibroblasts emerge via epithelial-mesenchymal
transition in chronic ki Page 1 [Frontiers in Bioscience 13, 6991-6998, May 1, 2008] 6991 …

Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Aberrant and
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …